Research Journal of Pharmaceutical Dosage Form and Technology

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Formulation, Evaluation and Validation of Dispersible tablet of Amoxycillin Sodium plus Cloxacillin Sodium


Affiliations
1 Manoharbhai Patel Institute of Pharmacy (B. Pharma), Gondia (MS) 441614, India
2 Sharad Pawar College of Pharmacy, Wanadongri, Nagpur (MS), India
     

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Dispersible tablet of amoxicillin sodium and cloxacillin sodium were prepared by employing different superdisintegrants and disintegrants such as microcrystalline cellulose and sodium starch glycolate, crosscarmellose sodium, crosspovidon, in different concentrations by direct compression method, formulation were evaluated for the standard of dispersible tablets and were compare with marketed product. The formulated tablets fulfilled all official (I.P.) requirement of dispersible tablet and give fast dissolution of amoxicillin plus cloxacillin sodium when compared to conventional marketed tablet of same drug. Study reveals that Dispersible tablet formulated by osscarmellose sodium employing gave fastest dissolution of amoxicillin plus cloxacillin sodium.

Keywords

Dispersible Tablet, Direct Compression, Amoxicillin And Cloxacillin Sodium, Sodium Starch Glycolate, Carmellose Sodium, Crospovidon, Superdisintegrants.
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  • Formulation, Evaluation and Validation of Dispersible tablet of Amoxycillin Sodium plus Cloxacillin Sodium

Abstract Views: 230  |  PDF Views: 0

Authors

P. G. Bhange
Manoharbhai Patel Institute of Pharmacy (B. Pharma), Gondia (MS) 441614, India
A. P. Mehere
Sharad Pawar College of Pharmacy, Wanadongri, Nagpur (MS), India
T. P. Nimbekar
Manoharbhai Patel Institute of Pharmacy (B. Pharma), Gondia (MS) 441614, India
P. P. Katolkar
Manoharbhai Patel Institute of Pharmacy (B. Pharma), Gondia (MS) 441614, India

Abstract


Dispersible tablet of amoxicillin sodium and cloxacillin sodium were prepared by employing different superdisintegrants and disintegrants such as microcrystalline cellulose and sodium starch glycolate, crosscarmellose sodium, crosspovidon, in different concentrations by direct compression method, formulation were evaluated for the standard of dispersible tablets and were compare with marketed product. The formulated tablets fulfilled all official (I.P.) requirement of dispersible tablet and give fast dissolution of amoxicillin plus cloxacillin sodium when compared to conventional marketed tablet of same drug. Study reveals that Dispersible tablet formulated by osscarmellose sodium employing gave fastest dissolution of amoxicillin plus cloxacillin sodium.

Keywords


Dispersible Tablet, Direct Compression, Amoxicillin And Cloxacillin Sodium, Sodium Starch Glycolate, Carmellose Sodium, Crospovidon, Superdisintegrants.