Preparation and In Vitro Evaluation of Aceclofenac Loaded Eudragit Microspheres

Aceclofenac is a non-steroidal anti-inflammatory drug. NSAIDs are chemically heterogeneous group of compounds including the sub-class of COX-2 inhibitor. The most available traditional NSAIDs act by inhibiting the prostaglandin synthases enzymes known as the cyclooxygenases. Aceclofenac microspheres were prepared using solvent evaporation technique. The drug : polymer combination such as Eudragit RL 100.The microspheres were evaluated with particle size, size distribution, scanning electron microscopy, encapsulation efficiencies, higuchi release and in vitro drug release study (percent cumulative drug release) using paddle dissolution method.