Proniosomal Gel as a Carrier for Improved Transdermal Delivery of Griseofulvin: Preparation and In-Vitro Characterization

The present investigation aimed at formulation, and performance evaluation of vesicular drug carrier system proniosomal gel for transdermal delivery of antifungal agent, griseofulvin. Proniosomal gel (PNG) formulations of griseofulvin were prepared, and characterized for vesicles shape, size, entrapment efficiency, and drug permeation across pig ear skin. The effects of different non-ionic surfactants on transdermal permeability profile were assessed. The optimized PNG formulation showed enhanced in vitro skin permeation flux of 3.682±0.186 μg/cm2/hr as compared to 0.028 ± 0.02 μg/cm2/hr for plain drug solution in water. Results indicated that the optimized PNG formulation of griseofulvin had better skin permeation potential than plain drug solution in water.