Characterization and Evaluation of Glibenclamide Transmucosal Drug Delivery System

In an attempt to develop mucoadhesive buccal drug delivery system, buccal tablets of Glibenclamide were prepared using polymers such as carbopol-934, Hydroxypropylmethyl cellulose HPMCK4M, and sodium carboxy methyl cellulose (Sod. CMC) in various proportions and combinations. The tablets were evaluated for different physicochemical parameters like weight variation, friability, hardness, drug content, water absorption studies, bioadhesive performance, release characteristics and surface pH. Tablets containing carbopol-934 and sodium CMC showed a maximum in vitro release of 82.27%. The formulations were subjected to graphical treatments according to Higuchi's equation and Peppa's equation. The best formulation F1 confirmed that the release mechanism is by diffusion, the rate of release following first order kinetic model.