Transdermal Drug Delivery System of Salbutamol Sulphate:Formulation and Evaluation

Salbutamol Sulphate (SS) is a selective 2 adrenergic receptor agonist having oral bioavailability of 50%. The transdermal films of SS were formulated using solvent casting technique. Solutions containing polymers i.e. Hydroxy Propyl Methyl Cellulose (HPMC) and Ethyl Cellulose (EC) at different concentrations (1%, 1.5%, 2%, 2.5%, and 3%) were prepared. These solutions were then used to prepare films. Prepared films were then evaluated for their different physicochemical parameters like physical appearance, weight variation, thickness, drug content, folding endurance, tensile strength, percent elongation and finally in vitro release study across rat abdominal skin. Between the two polymers used results revealed that the films prepared by using 2% HPMC with 30% propylene glycol(PG) was very flexible with high folding endurance and uniform drug content, further release study showed 88.68% release across the rat abdominal skin for 24 hours.