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Formulation and Evaluation of Chronomodulated Drug Delivery System


Affiliations
1 Department of Pharmaceutics, Dr. D. Y. Patil Institute of Pharmaceutical Sciences and Research, Pimpri, Pune-411018, India
2 Dr. D. Y. Patil Institute of Pharmaceutical Sciences and Research, Pimpri, Pune-411018, India
3 Microlabs Pvt. Ltd., Banglore, India
     

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A pulsatile drug delivery system which is time dependent, consist of an effervescent core surrounded by consecutive layers of swelling and rupturable layers were prepared and evaluated. The cores comprising of the active agent Terbutaline sulphate (β2 blocker) was prepared by direct compression method using different ratios of Microcrystalline cellulose, Osmotic agent and effervescent agent. The outer rupturable layer consists of Eudragit RS/RL (1:1) which surround the inner swelling layer comprising of Hydroxy propyl methyl cellulose E5. The effect of various formulation and processing parameters were studied. The rupture and drug release studies were carried out using the USP paddle method at 50 rpm in 0.1 N HCl, and Phosphate buffer pH 6.8. The lag time of drug release was increased by increasing the rupturable layer and decreased by increasing the swelling layer level. The osmotic and the effervescent effect were involved in the drug release, as shown by the studies.


Keywords

Nocturnal Asthma, Chronomudulated Drug Delivery, Terbutaline Sulphate, Swelling Layer, Rupturable Layer.
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  • Formulation and Evaluation of Chronomodulated Drug Delivery System

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Authors

Mukund G. Tawar
Department of Pharmaceutics, Dr. D. Y. Patil Institute of Pharmaceutical Sciences and Research, Pimpri, Pune-411018, India
Satish V. Shirolkar
Dr. D. Y. Patil Institute of Pharmaceutical Sciences and Research, Pimpri, Pune-411018, India
Mahesh D. Pawar
Microlabs Pvt. Ltd., Banglore, India
Nishant S. Gandhi
Dr. D. Y. Patil Institute of Pharmaceutical Sciences and Research, Pimpri, Pune-411018, India
Nilesh B. Deore
Dr. D. Y. Patil Institute of Pharmaceutical Sciences and Research, Pimpri, Pune-411018, India

Abstract


A pulsatile drug delivery system which is time dependent, consist of an effervescent core surrounded by consecutive layers of swelling and rupturable layers were prepared and evaluated. The cores comprising of the active agent Terbutaline sulphate (β2 blocker) was prepared by direct compression method using different ratios of Microcrystalline cellulose, Osmotic agent and effervescent agent. The outer rupturable layer consists of Eudragit RS/RL (1:1) which surround the inner swelling layer comprising of Hydroxy propyl methyl cellulose E5. The effect of various formulation and processing parameters were studied. The rupture and drug release studies were carried out using the USP paddle method at 50 rpm in 0.1 N HCl, and Phosphate buffer pH 6.8. The lag time of drug release was increased by increasing the rupturable layer and decreased by increasing the swelling layer level. The osmotic and the effervescent effect were involved in the drug release, as shown by the studies.


Keywords


Nocturnal Asthma, Chronomudulated Drug Delivery, Terbutaline Sulphate, Swelling Layer, Rupturable Layer.