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Compatibility Studies between Gatifloxacin and Pharmaceutical Excipients through Differential Scanning Calorimetry and Infra Red Spectroscopy


Affiliations
1 University Institute of Pharmacy, Pt. Ravishankar Shukla University, Raipur (C.G.) 492010, India
2 Aristo Pharmaceutical Mandideep, Bhopal (M.P.), India
     

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Proper formulation is an important aspect of any dosage form design. FTIR and Differential scanning calorimeter were used to evaluate the compatibility of Gatifloxacin and selected Excipients used in the development of suspensions formulation. In the first phase of Differential scanning calorimeter was used in the any interaction. In the next phase, excipients defined as prototype formula were tested for their compatibility with Gatifloxacin. Based on the results, methyl paraben and polyvinyl pyrrolidone were found show interaction with Gatifloxacin. Results of Differential scanning calorimeter and FT-IR demonstrated incompatibility between Gatifloxacin and MethylParaben. All the excipients defined in the prototype formula were found to be compatible with Gatifloxacin. Using the Excipients that were found to be compatible with Gatifloxacin. FT-IR and Differential scanning calorimetry was used to investigate the physicochemical compatibility between Gatifloxacin and various used in suspension manufacturing. The Gatifloxacin found to be compatatible with polyvinyl alcohol and acacia. Although interactions of Gatifloxacin with methyl paraben, polyvinyl pyrrolidone were observed. It cannot be conclusive stasted that interactions incompatibility will occur during storage at room temperature.

Keywords

Gatifloxacin, FTIR, Differential Scanning Calorimetry, Pharmaceutical Excipents, Preformulation Compatibility.
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  • Compatibility Studies between Gatifloxacin and Pharmaceutical Excipients through Differential Scanning Calorimetry and Infra Red Spectroscopy

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Authors

Rajendra Jangde
University Institute of Pharmacy, Pt. Ravishankar Shukla University, Raipur (C.G.) 492010, India
Rahul Singhour
Aristo Pharmaceutical Mandideep, Bhopal (M.P.), India
S. J. Daharwal
University Institute of Pharmacy, Pt. Ravishankar Shukla University, Raipur (C.G.) 492010, India

Abstract


Proper formulation is an important aspect of any dosage form design. FTIR and Differential scanning calorimeter were used to evaluate the compatibility of Gatifloxacin and selected Excipients used in the development of suspensions formulation. In the first phase of Differential scanning calorimeter was used in the any interaction. In the next phase, excipients defined as prototype formula were tested for their compatibility with Gatifloxacin. Based on the results, methyl paraben and polyvinyl pyrrolidone were found show interaction with Gatifloxacin. Results of Differential scanning calorimeter and FT-IR demonstrated incompatibility between Gatifloxacin and MethylParaben. All the excipients defined in the prototype formula were found to be compatible with Gatifloxacin. Using the Excipients that were found to be compatible with Gatifloxacin. FT-IR and Differential scanning calorimetry was used to investigate the physicochemical compatibility between Gatifloxacin and various used in suspension manufacturing. The Gatifloxacin found to be compatatible with polyvinyl alcohol and acacia. Although interactions of Gatifloxacin with methyl paraben, polyvinyl pyrrolidone were observed. It cannot be conclusive stasted that interactions incompatibility will occur during storage at room temperature.

Keywords


Gatifloxacin, FTIR, Differential Scanning Calorimetry, Pharmaceutical Excipents, Preformulation Compatibility.