Research Journal of Pharmaceutical Dosage Form and Technology

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Enhancement of Dissolution Rate Studies on Solid Dispersion of Aceclofenac


Affiliations
1 Department of Pharmaceutics, Padmavathi College of Pharmacy, Dharmapuri (DT), India
2 Padmavathi College of Pharmacy, Dharmapuri (DT), Tamil Nadu, India
     

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Aceclofenac is a Non- Steroidal Anti Inflammatory drug indicated for the relief of pain and inflammation, associated with rheumatoid arthritis, osteo arthritis, ankylosing, spondylitis. The percentage of dissolution rate of drug released from pure Aceclofenac was obtained 26.48% in 180min. The aim of the study was to enhance the dissolution rate on solid dispersion of Aceclofenac by using PEG6000 as carrier in three different ratios such as ACF:PEG6000-1:1, 1:2 and 1:4 by fusion method or melting method. The percentage of drug release of Aceclofenac from solid dispersions ACF:PEG6000-1:1,1:2 and 1:4 was 59.65%,84.75%,98.34% respectively in 180min. Aceclofenac from solid dispersions due to enhancing effect of PEG6000.


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  • Enhancement of Dissolution Rate Studies on Solid Dispersion of Aceclofenac

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Authors

S. Lakshmi Thotacherla
Department of Pharmaceutics, Padmavathi College of Pharmacy, Dharmapuri (DT), India
A. M. Shamsunisha
Department of Pharmaceutics, Padmavathi College of Pharmacy, Dharmapuri (DT), India
Y. Sirisha
Department of Pharmaceutics, Padmavathi College of Pharmacy, Dharmapuri (DT), India
C. Valarmathi
Department of Pharmaceutics, Padmavathi College of Pharmacy, Dharmapuri (DT), India
K. L. Senthilkumar
Padmavathi College of Pharmacy, Dharmapuri (DT), Tamil Nadu, India
Ezhilmuthu
Department of Pharmaceutics, Padmavathi College of Pharmacy, Dharmapuri (DT), India
A. Vasanthan
Department of Pharmaceutics, Padmavathi College of Pharmacy, Dharmapuri (DT), India
P. Sumathy
Department of Pharmaceutics, Padmavathi College of Pharmacy, Dharmapuri (DT), India

Abstract


Aceclofenac is a Non- Steroidal Anti Inflammatory drug indicated for the relief of pain and inflammation, associated with rheumatoid arthritis, osteo arthritis, ankylosing, spondylitis. The percentage of dissolution rate of drug released from pure Aceclofenac was obtained 26.48% in 180min. The aim of the study was to enhance the dissolution rate on solid dispersion of Aceclofenac by using PEG6000 as carrier in three different ratios such as ACF:PEG6000-1:1, 1:2 and 1:4 by fusion method or melting method. The percentage of drug release of Aceclofenac from solid dispersions ACF:PEG6000-1:1,1:2 and 1:4 was 59.65%,84.75%,98.34% respectively in 180min. Aceclofenac from solid dispersions due to enhancing effect of PEG6000.