Solubility Enhancement of Aceclofenac Using Dendrimer

In the present study we investigated the effect of generation 3 (G3) PAMAM dendrimer on the aqueous solubility of aceclofenac. The aqueous solubility of aceclofenac was measured in the presence of dendrimer. A 32 full factorial design was employed. The concentration of dendrimer and temperature were used as independent variables, while solubility of drug was selected as dependent variable. The experimental results showed that the aqueous solubility of aceclofenac was directly proportional to concentration of dendrimer and inversely proportional to the temperature under the experiment performed. Under the suitable condition, the solubility of aceclofenac can improves with the PAMAM dendrimer.