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Comparative In-Vitro Evaluation of Marketed Paracetamol Tablets


Affiliations
1 Sultan–Ul–Uloom College of Pharmacy, Road No.3, Banjarahills, Hyderabad- 500034, (A.P.), India
2 Sultan–Ul–Uloom College of Pharmacy, Road No.3, Banjarahills, Hyderabad-500034, (A.P.), India
     

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The aim of the present study is to investigate the physicochemical equivalence of five brands of tablets containing paracetamol purchased from different retail pharmacy outlets in Hyderabad, Andhrapradesh, India. The tablets were evaluated for uniformity of weight, friability, hardness, thickness, disintegration, dissolution and assay. All the five brands of the tablets passed the Indian Pharmacopoeia (IP) standards for all in vitro evaluation tests. There was no significant difference in the amount of paracetamol released from the different brands (P>0.05). These results indicate that the tablets of paracetamol purchased from retail outlets in Hyderabad are manufactured and marketed from WHO GMP certified Indian companies. Further work is recommended on bioequivalence of these tablets.

Keywords

Paracetamol, Tablets, Evaluation, Marketed.
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  • Comparative In-Vitro Evaluation of Marketed Paracetamol Tablets

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Authors

T. Mamatha
Sultan–Ul–Uloom College of Pharmacy, Road No.3, Banjarahills, Hyderabad- 500034, (A.P.), India
Md. Raheem
Sultan–Ul–Uloom College of Pharmacy, Road No.3, Banjarahills, Hyderabad-500034, (A.P.), India
S. Imam Pasha
Sultan–Ul–Uloom College of Pharmacy, Road No.3, Banjarahills, Hyderabad-500034, (A.P.), India
Md. Zubair
Sultan–Ul–Uloom College of Pharmacy, Road No.3, Banjarahills, Hyderabad-500034, (A.P.), India

Abstract


The aim of the present study is to investigate the physicochemical equivalence of five brands of tablets containing paracetamol purchased from different retail pharmacy outlets in Hyderabad, Andhrapradesh, India. The tablets were evaluated for uniformity of weight, friability, hardness, thickness, disintegration, dissolution and assay. All the five brands of the tablets passed the Indian Pharmacopoeia (IP) standards for all in vitro evaluation tests. There was no significant difference in the amount of paracetamol released from the different brands (P>0.05). These results indicate that the tablets of paracetamol purchased from retail outlets in Hyderabad are manufactured and marketed from WHO GMP certified Indian companies. Further work is recommended on bioequivalence of these tablets.

Keywords


Paracetamol, Tablets, Evaluation, Marketed.