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Preparation and Evaluation of Transdermal Films of Oxybutynin


Affiliations
1 Department of Pharmaceutics, M.M.U College of Pharmacy, K, K, Doddi, Dist. Ramanagara- 571511,Karnataka, India
2 Department of Pharmaceutical Chemistry, M.M.U College of Pharmacy, K, K, Doddi, Dist. Ramanagara- 571511, Karnataka, India
     

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Overactive bladder (OAB) is a chronic and distressing medical condition characterized by urinary urgency and frequency with or without urge incontinence that often requires long term treatment to maintain control of symptoms. Oxybutynin is an anticholinergic drug used to treat OAB. The transdermal films of oxybutynin were formulated using solvent casting technique. Solutions containing polymers (HPMC, Ethyl cellulose) at different concentrations (2%, 3% and 4% w/w) were prepared. These solutions were then used to prepare films. Prepared films were then evaluated for various physicochemical properties like physical appearance, weight variation, thickness, drug content, folding endurance percentage elongation and tensile strength including in vitro studies. Between the two polymers used results showed that the formulation HE2 prepared in combination of HPMC: ethyl cellulose (3:1) with 30% propylene glycol was very flexible with highest folding endurance and uniform drug content. Further permeation study for HE2 shows 88.58% release across the rat abdominal skin for 24 hours.

Keywords

Overactive Bladder, Solvent Casting Technique, Oxybutynin.
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  • Preparation and Evaluation of Transdermal Films of Oxybutynin

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Authors

T. S Vaseeha Banu
Department of Pharmaceutics, M.M.U College of Pharmacy, K, K, Doddi, Dist. Ramanagara- 571511,Karnataka, India
Sukhen Som
Department of Pharmaceutical Chemistry, M.M.U College of Pharmacy, K, K, Doddi, Dist. Ramanagara- 571511, Karnataka, India

Abstract


Overactive bladder (OAB) is a chronic and distressing medical condition characterized by urinary urgency and frequency with or without urge incontinence that often requires long term treatment to maintain control of symptoms. Oxybutynin is an anticholinergic drug used to treat OAB. The transdermal films of oxybutynin were formulated using solvent casting technique. Solutions containing polymers (HPMC, Ethyl cellulose) at different concentrations (2%, 3% and 4% w/w) were prepared. These solutions were then used to prepare films. Prepared films were then evaluated for various physicochemical properties like physical appearance, weight variation, thickness, drug content, folding endurance percentage elongation and tensile strength including in vitro studies. Between the two polymers used results showed that the formulation HE2 prepared in combination of HPMC: ethyl cellulose (3:1) with 30% propylene glycol was very flexible with highest folding endurance and uniform drug content. Further permeation study for HE2 shows 88.58% release across the rat abdominal skin for 24 hours.

Keywords


Overactive Bladder, Solvent Casting Technique, Oxybutynin.