Taste Masking and Evaluation of Rapid Disintegrating Tablet of Gatifloxacin Sesquihydrate

Gatifloxacin Sesquihydrate is a Broad Spectrum Antimicrobial agent active against Gram Positive and Gram Negative Organism. It is slightly bitter in taste. In the present study an attempt has been made to prepare bitterless fast dissolving tablet of Gatifloxacin Sesquihydrate using Indion 204, Indion 214, Indion 234, Tulsion 335 (ion exchange resin) as a taste masking agent. X-ray powder diffractometry, FT-IR spectroscopy and differential scanning calorimetry were used to investigate the physical characteristics of the crystals. The tablet was prepared by Wet granulation technique with three super disintegrants e.g. sodium starch glycolate, crosscarmellose sodium and crospovidone. The granules were examined for angle of repose, bulk density, tapped density and hausner’s ratio. The tablets were evaluated for hardness, drug content and friability and disintegration time. The disintegration in oral cavity was also tested and was found to be 22 sec. Also In-Vivo and In-Vitro taste Evaluation of Solid Drug: Resin Complex was carried out.