Design and Evaluation of Mucoadhesive Tablets of Lorsatan Potassium

Mucoadhesive tablets of Lorsatan Potassium were prepared using carbopol-940P, Sodium carboxy methyl cellulose (SCMC), hydroxy propyl methyl cellulose (HPMC), ethyl cellulose (EC) and Eudragit-RL100 as mucoadhesive polymers. Eight formulations were developed with varying concentrations of polymers. The SCMC is used as a primary polymer because of its excellent mucoadhesive property and secondary polymers like HPMC, EC, Carbopol-940P and Eudragit RL-100 were used. The formulations were evaluated for in-vitro drug release, in-vitro swelling studies and in-vitro bioadhesive strength studies. Formulation R-03 showed maximum release of 95.68% in 10hours and maximum swelling index of 99.59 % after 10hours, also showed highest bioadhesion. FTIR studies show no evidence on interaction between drug and polymers. The results indicate that suitable mucoadhesive tablets with desired properties could be prepared.