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Physicochemical Characterization of Solid Dispersion of Cefexime with Poloxamer 188


Affiliations
1 Dept. of Pharmaceutical Chemistry, Govt. College of Pharmacy, Karad, (M.S.), India
2 Department of Pharmaceutical Chemistry, Govt. College of Pharmacy, Karad, (M.S.), India
3 Gangamai College of Pharmacy, Nagaon, Dhule, (M.S.), India
4 KYDSCT's College of Pharmacy, Sakegaon, Tal. Bhusawal, Dist. Jalgaon (M.S.), India
     

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This study compares the physicochemical properties of cefixime (CFX) solid dispersions prepared by freeze drying method. Solid dispersions of cefixime in poloxamer 188 were prepared and characterized by intrinsic dissolution, powder X-ray diffraction, Fourier transform infrared spectroscopy and Scanning electron microscopy. CFX:Poloxamer 188 solid dispersions showed increased dissolution rate than pure CFX. The Infrared spectroscopic studies showed interaction between CFX and Poloxamer 188 in solid dispersions. The scanning electron microscopy studies showed decrease in particle size of binary system as compared to particle of pure drug. The amorphous state of CFX coupled with presence of interaction between drug and Poloxamer 188. However, the antimicrobial activity of CFX was increased significantly by Poloxamer 188 against S. aureus and E. coli. The solid dispersion technique of CFX:Poloxamer 188 binary system provides a promising way to increase the solubility and dissolution rate of poorly soluble drugs.

Keywords

Cefixime, Solid Dispersion, Poloxamer 188, Freeze Drying, Dissolution Rate, Binary System.
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  • Physicochemical Characterization of Solid Dispersion of Cefexime with Poloxamer 188

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Authors

D. S. Saindane
Dept. of Pharmaceutical Chemistry, Govt. College of Pharmacy, Karad, (M.S.), India
A. S. Kulkarn
Department of Pharmaceutical Chemistry, Govt. College of Pharmacy, Karad, (M.S.), India
A. N. Sagri
Department of Pharmaceutical Chemistry, Govt. College of Pharmacy, Karad, (M.S.), India
R. B. Pimprikar
Gangamai College of Pharmacy, Nagaon, Dhule, (M.S.), India
S. B. Yeshwante
Gangamai College of Pharmacy, Nagaon, Dhule, (M.S.), India
C. P. Suryawanshi
Gangamai College of Pharmacy, Nagaon, Dhule, (M.S.), India
S. D. Firke
KYDSCT's College of Pharmacy, Sakegaon, Tal. Bhusawal, Dist. Jalgaon (M.S.), India
M. K. Kale
KYDSCT's College of Pharmacy, Sakegaon, Tal. Bhusawal, Dist. Jalgaon (M.S.), India

Abstract


This study compares the physicochemical properties of cefixime (CFX) solid dispersions prepared by freeze drying method. Solid dispersions of cefixime in poloxamer 188 were prepared and characterized by intrinsic dissolution, powder X-ray diffraction, Fourier transform infrared spectroscopy and Scanning electron microscopy. CFX:Poloxamer 188 solid dispersions showed increased dissolution rate than pure CFX. The Infrared spectroscopic studies showed interaction between CFX and Poloxamer 188 in solid dispersions. The scanning electron microscopy studies showed decrease in particle size of binary system as compared to particle of pure drug. The amorphous state of CFX coupled with presence of interaction between drug and Poloxamer 188. However, the antimicrobial activity of CFX was increased significantly by Poloxamer 188 against S. aureus and E. coli. The solid dispersion technique of CFX:Poloxamer 188 binary system provides a promising way to increase the solubility and dissolution rate of poorly soluble drugs.

Keywords


Cefixime, Solid Dispersion, Poloxamer 188, Freeze Drying, Dissolution Rate, Binary System.