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Design and Evaluation of Ranitidine Hydrochloride Floating Tablets for Oral Controlled Release


Affiliations
1 GRY institute of Pharmacy, Vidhya Vihar, Borawan, M.P, India
2 Girijanada Chowdhury Institute of Pharmaceutical Science, Azara Hathakhowapara, NH-37, Guwahati 781017, Assam, India
3 Department of Pharmaceutics, GRY institute of Pharmacy, Vidhya Vihar, Borawan, M.P, India
     

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The purpose of the study was to develop a floating control drug delivery system of ranitidine hydrochloride and investigate the effect of formulation variables on drug release profile and floating property. Ranitidine hydrochloride (RHCl) was used as a model drug because of its short biological half life and site of release at stomach. Tablets were formulated using different concentration hydroxypropyl methyl cellulose K4M, carbopol 934.where Sodium bicarbonate and Citric acid used as a gas generating agent. The floating behavior and in-vitro dissolution studies are carried out in a USP type II apparatus in 0.1 (N) HCL. It was observed that all the prepared formulation shows good floating capabilities up to 15 to 18 hours and slow steady release profile up to 12 hours. The dissolution profiles were subjected various kinetic release equations and found that drug release from different polymeric matrix follows diffusion controlled process. It has been also observed that combination of HPMC K4M and carbopol 934 shows better results as compared to their single use.

Keywords

Floating Controlled Delivery System, Ranitidine Hydrochloride, Hydroxypropyl Methylcellulose K4 M, Carbopol-934.
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  • Design and Evaluation of Ranitidine Hydrochloride Floating Tablets for Oral Controlled Release

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Authors

A. Choudhury
GRY institute of Pharmacy, Vidhya Vihar, Borawan, M.P, India
S. K. Dash
Girijanada Chowdhury Institute of Pharmaceutical Science, Azara Hathakhowapara, NH-37, Guwahati 781017, Assam, India
A. Roy
Department of Pharmaceutics, GRY institute of Pharmacy, Vidhya Vihar, Borawan, M.P, India
S. Bahadur
Department of Pharmaceutics, GRY institute of Pharmacy, Vidhya Vihar, Borawan, M.P, India
S. Saha
Department of Pharmaceutics, GRY institute of Pharmacy, Vidhya Vihar, Borawan, M.P, India
S. Das
Department of Pharmaceutics, GRY institute of Pharmacy, Vidhya Vihar, Borawan, M.P, India

Abstract


The purpose of the study was to develop a floating control drug delivery system of ranitidine hydrochloride and investigate the effect of formulation variables on drug release profile and floating property. Ranitidine hydrochloride (RHCl) was used as a model drug because of its short biological half life and site of release at stomach. Tablets were formulated using different concentration hydroxypropyl methyl cellulose K4M, carbopol 934.where Sodium bicarbonate and Citric acid used as a gas generating agent. The floating behavior and in-vitro dissolution studies are carried out in a USP type II apparatus in 0.1 (N) HCL. It was observed that all the prepared formulation shows good floating capabilities up to 15 to 18 hours and slow steady release profile up to 12 hours. The dissolution profiles were subjected various kinetic release equations and found that drug release from different polymeric matrix follows diffusion controlled process. It has been also observed that combination of HPMC K4M and carbopol 934 shows better results as compared to their single use.

Keywords


Floating Controlled Delivery System, Ranitidine Hydrochloride, Hydroxypropyl Methylcellulose K4 M, Carbopol-934.