Studies on Occlusion Complexes of Aceclofenac with β-Cyclodextrin and Hydroxypropyl -β- Cyclodextrin

The present study is aimed at improving the dissolution of poorly water soluble Aceclofenac by complexation with β-cyclodextrin and Hydroxypropyl- β-cyclodextrin. Bioavailability of such drug may be enhanced by improving its solubility and dissolution rate. The objective of present study is to increase the solubility and dissolution rate of Aceclofenac by preparing its occlusion complexes with β-cyclodextrin and Hydroxypropyl-β-cyclodextrin in different molar ratios using kneading method. The prepared complexes were characterized for drug content, differential scanning calorimetry, FTIR spectral studies, phase solubility and in-vitro dissolution profile. DSC and FTIR spectral studies performed on solid complexes have confirmed the inclusion complexation between drug and Cyclodextrins. It has been observed that solubility and dissolution rate increased to greater extent for Hydroxypropyl-β-cyclodextrin than β-cyclodextrin and that of pure drug.