Optimization of Coating Solution for Preparation of Sustained Release Tablet

In this study, tablets were formulated by wet granulation technique taking Paracetamol as model drug. Three mucoadhesive polymers namely hydroxyl propyl methyl cellulose K4M, methyl cellulose and poly vinyl pyrolidone were used for preparation of coating solution (1%,2% and 3%) as well as for development of sustained release tablets. All the evaluation were carried out before and after coating like thickness and diameter, weight variation, friability, disintegration, swelling index, Mucoadhesive strength, drug content and in-vitro release study. All the physical evaluation parameters were increases after coating when compare with normal tablet. Normal tablets were showed 95% release within 30 min where coated tablets showed 98% release over a period of 6hr. in water and release was diffusion controlled confirmed by Higuchi’s plot. Thus, the present study concluded that, we can development of sustained release formulation can be possible by coating using the mucoadhesive polymers.