In-Vitro Release Kinetic Study of Mosapride Citrate Dihydrate from Sustained Release Matrix Tablet Containing Two Different Viscosity Grades of HPMC

The objective of the present study was to develop once daily sustained release matrix tablet of Mosapride or its pharmaceutically acceptable salts with pharmaceutically acceptable excipients. The matrix tablets were prepared by dry granulation (slugging/roller compaction) technique by using hydrophilic matrix polymer such as hydroxyl propyl methyl cellulose (HPMC) of two different viscosity grades. The granules were evaluated for bulk density, tapped density, angle of repose, compressibility index etc. The prepared matrix tablets were taken for release study. The results of invitro dissolution study shown that the formulation F6 (HPMC K4M: HPMC K15M) 1:1.235, exhibited satisfactory drug release pattern and total drug release pattern was very close to theoretical release profile. The mechanism of the drug release from sustained release matrix tablet of formulation F6 was fickanian diffusion.