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Development and Characterization of a Stable Suspension of Rifampicin and Isoniazid
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Rifampicin (RMP) and Isoniazid (INH) are highly unstable in liquid dosage form and there is no liquid product available. A novel concept of formulating a suspension of RMP and INH for pediatric and geriatric application has been tried. The reconstitutable dry syrup which can be reconstituted by using a special vehicle has shown very good stability at 2- 80C and at 250C for more than 1 month and 14 days respectively using a stability indicating HPLC method. The in vitro dissolution studies have revealed no adverse impact of special vehicle on dissolution. Thus this combination product could prove to be a major boost for the market need for pediatric patients.
Keywords
Rifampicin, Isoniazid, Suspension, Stability.
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