Effect of Superdisintegrants on Olanzapine Oro-Dispersible Tablets

This study investigated to compare the disintegration efficiency for the 5 classes of superdisintegrants represented by Cros-carmellose Sodium (CCS), Cros-povidone (CP), Polacrilin K (PK), Sodium Starch Glycolate (SSG), and L-Hydroxy Propyl Cellulose (L-HPC). Tablets were prepared by direct compression method. Effect of 5 superdisintegrants on disintegration time, dissolution parameters, and friability has been studied. Among all the superdisintegrants, a PK containing tablets has shown faster disintegration followed by SSG. Tablets containing L-HPC disintegrated after PK and SSG containing tablets. Where as disintegration time and dissolution parameters increased with increase in the level of Cros-carmellose in tablets. However the disintegration time value did not reflect in dissolution parameter values of cros-povidone tablets and release was dependent on aggregate size in dissolution medium.