Minitablet: A Novel Approach for Oral Extended Release

The present study is carried out to compare matrix tablets and mini tablets of Diltiazem hydrochloride. Matrix tablets and mini-matrix tablets containing Diltiazem hydrochloride have been prepared by wet granulation technique. The hydrophilic matrix was formed with chitosan together with the additives. Preparation, the swelling and erosion behavior, in-vitro release profiles and release kinetics and mechanism of release are discussed. Comparison of all the parameters of matrix and mini matrix tablets is discussed. The result shows that mini matrix tablets shows more extended release profile in comparison with the matrix tablets under similar conditions.