Design, Development and Optimization of Extended Release Matrix Tablet for Broad Spectrum Antibiotics

A floating extended release formulation of a broad spectrum antibiotics containing ciprofloxacin and Amoxicillin have been prepared by a unique blend of polymer (HPMC) matrix, NaHCO₃ (Sodium bicarbonate) and other excipients in a optimized ratio to achieve an extended or delayed drug release profile up to 12 hours without any chemical interaction between drug and excipients. A unique blend of polymer matrix has been made by two different grades (K4M-low viscosity and K15M-high viscosity) of 'hydroxypropylmethyl cellulose' (HPMC) in a optimized ratio of 1: 35.66 (HPMC K4M: HPMC K15M) to reach the targeted drug release profile. The in vitro dissolution study shows that the floating tablets are capable of drug release over a period of 12 hours. The treated data are fitted into various kinetic models and R² values are evaluated. The analysis shows that the drug release from the floating matrix followed Higuchi release kinetics more preferably. As the "n" (release exponent) values of Krosmeyer-Pappes model of most of the formulation batch are in the range of 0.5-0.89 and 0.89-1.0.