Research Journal of Pharmaceutical Dosage Form and Technology

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Formulation Techniques for Designing of Osmotic Controlled Drug Delivery Systems:A Review


Affiliations
1 Department of Pharmaceutics, University College of Technology, Osmania University, Hyderabad, Telangana-500007., India
2 Mekelle Institute of Technology, Mekelle University, Mekelle, Ethiopia
3 Department of Pharmaceutics, Malla Reddy College of Pharmacy (Affiliated to Osmania University), Maisammaguda, Secunderabad, Telangana-500014, India
4 Department of Pharmaceutical Technology, Netaji Institute of Pharmaceutical Sciences, Toopranpet, Yadadri Bhongir, Telangana – 508252, India
5 Department of Pharmaceutics, Anwarul Uloom College of Pharmacy, Newmallepally, Hyderabad, Telangana, India
     

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Osmotic drug delivery system (ODDS) provides the drug dose and dosing interval in optimized manner to maintain drug concentration within therapeutic window thus ensuring efficacy and minimizing toxic effects. The objective of ODDS is to release pharmacologically active ingredients in a predetermined, predictable and reproducible manner to systemic circulation. ODDS delivers a drug to large extent is independent of the physiological factors of the gastrointestinal tract, pH. Hence it can be utilized for systemic as well as targeted delivery of drugs. The release of drugs from osmotic system controls the drug release by controlling various formulation factors such as solubility, osmotic pressure of the core components, size of the delivery orifice and nature of the rate controlling membrane. The design of osmotic system is achieved by optimizing formulation and processing factors to deliver drugs in preprogrammed rate and controlled manner. In present study is an update on osmosis, different types of osmotic systems, components of ODDS, key parameter sand some patents.

Keywords

Osmotic Drug Delivery System, Osmosis, Osmotic Pressure.
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  • Formulation Techniques for Designing of Osmotic Controlled Drug Delivery Systems:A Review

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Authors

Chinmaya Keshari Sahoo
Department of Pharmaceutics, University College of Technology, Osmania University, Hyderabad, Telangana-500007., India
Surepalli Rammohan Rao
Mekelle Institute of Technology, Mekelle University, Mekelle, Ethiopia
Muvvala Sudhakar
Department of Pharmaceutics, Malla Reddy College of Pharmacy (Affiliated to Osmania University), Maisammaguda, Secunderabad, Telangana-500014, India
D. Venkata Ramana
Department of Pharmaceutical Technology, Netaji Institute of Pharmaceutical Sciences, Toopranpet, Yadadri Bhongir, Telangana – 508252, India
Kanhu Charan Panda
Department of Pharmaceutics, Anwarul Uloom College of Pharmacy, Newmallepally, Hyderabad, Telangana, India

Abstract


Osmotic drug delivery system (ODDS) provides the drug dose and dosing interval in optimized manner to maintain drug concentration within therapeutic window thus ensuring efficacy and minimizing toxic effects. The objective of ODDS is to release pharmacologically active ingredients in a predetermined, predictable and reproducible manner to systemic circulation. ODDS delivers a drug to large extent is independent of the physiological factors of the gastrointestinal tract, pH. Hence it can be utilized for systemic as well as targeted delivery of drugs. The release of drugs from osmotic system controls the drug release by controlling various formulation factors such as solubility, osmotic pressure of the core components, size of the delivery orifice and nature of the rate controlling membrane. The design of osmotic system is achieved by optimizing formulation and processing factors to deliver drugs in preprogrammed rate and controlled manner. In present study is an update on osmosis, different types of osmotic systems, components of ODDS, key parameter sand some patents.

Keywords


Osmotic Drug Delivery System, Osmosis, Osmotic Pressure.

References