Research Journal of Pharmaceutical Dosage Form and Technology

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Formulation and Evaluation of Effervescent Floating Tablets of Procainamide


Affiliations
1 Department of Pharmaceutics, Mother Teresa Pharmacy College, Sathupally, Khammam Dist, 507303, India
     

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The aim of the present study was to develop floating formulation of Procainamide to maintain constant therapeutic levels of the drug for over 10 hrs. Various eudragit polymers were employed as polymers. Procainamide dose was fixed as 20 mg. Total weight of the tablet was considered as 300 mg. Polymers were used in the concentration of 30,60 and 90 mg concentration. All the formulations were passed various physicochemical evaluation parameters and they were found to be within limits. Whereas from the dissolution studies it was evident that the formulation (F2) showed better and desired drug release pattern i.e., 99.4 % in 12 hours. It contains the eudragit polymer Procainamide as sustained release material. It followed zero order release kinetics mechanism.

Keywords

Procainamide, Eudragit (L 100, S 100, RSPO) Floating Tablets.
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  • Formulation and Evaluation of Effervescent Floating Tablets of Procainamide

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Authors

B. Saraswathi
Department of Pharmaceutics, Mother Teresa Pharmacy College, Sathupally, Khammam Dist, 507303, India
R. Jagadeesh Reddy
Department of Pharmaceutics, Mother Teresa Pharmacy College, Sathupally, Khammam Dist, 507303, India
P. Swathi
Department of Pharmaceutics, Mother Teresa Pharmacy College, Sathupally, Khammam Dist, 507303, India
G. Manasa
Department of Pharmaceutics, Mother Teresa Pharmacy College, Sathupally, Khammam Dist, 507303, India

Abstract


The aim of the present study was to develop floating formulation of Procainamide to maintain constant therapeutic levels of the drug for over 10 hrs. Various eudragit polymers were employed as polymers. Procainamide dose was fixed as 20 mg. Total weight of the tablet was considered as 300 mg. Polymers were used in the concentration of 30,60 and 90 mg concentration. All the formulations were passed various physicochemical evaluation parameters and they were found to be within limits. Whereas from the dissolution studies it was evident that the formulation (F2) showed better and desired drug release pattern i.e., 99.4 % in 12 hours. It contains the eudragit polymer Procainamide as sustained release material. It followed zero order release kinetics mechanism.

Keywords


Procainamide, Eudragit (L 100, S 100, RSPO) Floating Tablets.

References