![Open Access](https://i-scholar.in/lib/pkp/templates/images/icons/fulltextgreen.png)
![Restricted Access](https://i-scholar.in/lib/pkp/templates/images/icons/fulltextred.png)
![Open Access](https://i-scholar.in/lib/pkp/templates/images/icons/fulltextgreen.png)
![Open Access](https://i-scholar.in/lib/pkp/templates/images/icons/fulltext_open_medium.gif)
![Restricted Access](https://i-scholar.in/lib/pkp/templates/images/icons/fulltextred.png)
![Restricted Access](https://i-scholar.in/lib/pkp/templates/images/icons/fulltext_restricted_medium.gif)
Formulation Development and Evaluation of Buccal Patches of Aceclofenac for Gingivitis
Subscribe/Renew Journal
The aim of the present work is to develop the formulation and evaluate the buccal patches of aceclofenac for gingivitis using different mucoadhesive polymers such as hpmc 5cps, carbopol 934p, eudragit rl 100 in various combinations. Method: The buccal patches were prepared by solvent casting method. All the buccal formulations were subjected to preformulation and physical evaluation studies, in-vitro drug release and ex-vivo permeation studies. In-vitro drug release from the formulation was studied using buffer pH 6.8. Results: From in vitro studies formulation F6 and F7 were selected for mucoadhesive studies and ex vivo permeation studies using buffer Ph 6.8. After all studies, formulation F7 containing hpmc 5cps and eudragit rl 100 in the ratio (400 mg: 200 mg) was selected as optimized formulation and its muccoadhesive strength and exhibited optimum drug release. FTIR results showed no evidence of interaction between the drug and polymers. Conclusion: After evaluating the formulations it revealed that the drug content was within the limits. The results indicated that delivery of aceclofenac to the local drug delivery via the buccal route improve its bioavailability and also was found to be stable during stability studies conducted for 3 months as per ICH guidelines.
Keywords
Buccal Patches, Aceclofenac, Mucoadhesive Polymers, Physicochemical Parameters, In Vitro Drug Release, Mucoadhesive Studies, Ex Vivo Permeation Studies, Stability Studies.
Subscription
Login to verify subscription
User
Font Size
Information
- Cristina Cavallari, Adamo F B, Francesca O C. Mucoadhesive multiparticulate patch for the intrabuccal controlled delivery of lidocaine. European Journal of Pharmaceutics and Bio Pharmaceutics, 2013; 83: 405–414.
- Gowthamarajan, Sachin Kumar Singh, Dev Prakash, Somashekhar. Dissolution Enhancement of Poorly Soluble Aceclofenac by Solid Dispersion Technique and Its Comparison with Marketed Formulations, International Journal of Pharm Tech Research (IJPRI)., 2010; 2(4): 2347-2356.
- Harris D, Robinson J.R. Drug delivery via the mucous membranes of the oral cavity, J Pharm Sci., 1992; 18: 1-10.
- Humes, H. David, et al., Kelley's Textbook of Internal Medicine. 4th ed. Philadelphia, PA: Lippincott Williams and Wilkins., 2000.
- Patel VM, Prajapati BG, Patel MM. Design and characterization of chitosan containing mucoadhesive buccal patches of propranolol hydrochloride. Acta Pharm., 2007; 57: 61–72.
- Khairnar A, Jain P, Baviskar D, Jain D. Development of mucoadhesive buccal patch containing aceclofenac: in-vitro evaluation. Int J Pharm Sci., 2009; 1(1): 91–5.
- Shah Viral A, Shah Jimish, Upadhyay UM. Formulation development and evaluation of buccal bilyer patch using thiocolchicoside and diclofenac sodium, Int. J. Inv. Pharm. Sci., 2013; 1(3): 190-211.
- Dhagla Ram Choudhary, Vishnu A Patel, Usmangani K Chhalotiya, Harsha V Patel, Aliasgar J Kundawala. Natural Polysaccharides As Film Former: A Feasibility Study For Development Of Rapid Dissolving Films of Ondansetron Hydrochloride, Int J Pharm Pharm Sci., 2001; 3: 78-85.
- Tej Pratap Singh, Rakesh Kumar Singh, et al. Mucoadhesive bilayer buccal patches of verapamil hydrochloride: formulation development and characterization. Int J Pharm Pharm Sci., 2014; 6(4): 234;241.
- Burgalassi S A, Panichi L A et al. Development and in vitro/in vivo testing of mucoadhesive buccal patches releasing benzydamine and lidocaine, Int. J. Pharm., 1996; 133: 1-7.
- Faiyaz Shakeel, Mohammed S Faisal, Sheikh Shafiq. Comparative Pharmacokinetic Profile of Aceclofenac from Oral and Transdermal Application Journal of Bioequivalence and Bioavailability(JBB)., 2009; 1.
- Shivhare U D, Suruse P S, Varvandkar S S. Formulation and evaluation of buccal patch containing aceclofenac. J App Pharm., 2014: 6(1): 65-76.
- Mohamed S. Pendekaln, Pramod K, Tegginamat. Formulation and evaluation of a bioadhesive patch for buccal delivery of tizanidine. Acta Pharmaceutica Sinica B., 2012; 2(3): 318–324.
- Owens TS, Dansereau RJ, Sakr A. Development and evaluation of extended release bioadhesive sodium fluoride tablets, Int J Pharm., 2005; 288: 109–22.
- Lee VHL, Lee VHK, Robinson JR. Controlled Drug Delivery New York: Marcel Dekker Inc., 1987; 29(2): 4.
- Amir Shojaei H. Buccal mucosa as a route for systemic drug delivery. J Pharm Pharm Sci., 1998; 1(1): 15-30.
- Parthasarathy G, Bhaskar R Kesavan, Jayaveera K Narasimha, Formulation of unidirectional release buccal patches of carbamazepine and study of permeation through porcine buccal mucosa. Asian Pac J Trop Biomed, 2013; 3(12): 995-1002.
- Pendekaln M S, Tegginamat P K. Formulation and evaluation of a bioadhesive patch for buccal delivery of tizanidine. Acta Pharmaceutica Sinica B., 2(3): 318–24.
- K Balamurugan, J K Pandit, P K Choudary, J Balasubramaniam. Ind. J. Pharm. Sci., 2001; 63: 473-480.
- Schatzle M, Loe H, Burgin W, Anerud A, Boysen H, et al. Clinical course of chronic periodontitis. I. Role of gingivitis. J Clin Periodontol., 2003; 30: 887–901.
- Vashmi Vishnu Y, Chandrasekhar K, Ramesh G, Madhusudan Rao Y. Development of mucoadhesive patches for buccal administration of carvedilol. Curr Drug Deliv., 2007; 4: 27–39.
![](https://i-scholar.in/public/site/images/abstractview.png)
Abstract Views: 251
![](https://i-scholar.in/public/site/images/pdfview.png)
PDF Views: 0