Research Journal of Pharmaceutical Dosage Form and Technology

Open Access Open Access  Restricted Access Subscription Access
Open Access Open Access Open Access  Restricted Access Restricted Access Subscription Access

Bicalutamide Tablets by Spray Dried Microspheres:An Approach to Enhance Solubility


Affiliations
1 Rajarambapu College of Pharmacy, Kasegaon, Tal. Walwa, Dist. Sangli, Maharashtra, India
     

   Subscribe/Renew Journal


The aim of the present study was to enhance the dissolution rate of poorly water soluble drug, Bicalutamide. Bicalutamide is an antiandrogen agent used in the treatment of prostate cancer. To improve the dissolution rate of the drug, hydrophilic carriers like povidone K30 was and methanol was used for preparing microspheres. Microspheres of Bicalutamide were prepared by spray drying technique by using povidone K 30 at different concentrations. The microspheres were evaluated for drug release profile. The compatibility was studied by Fourier Transforms Infrared spectroscopy (FTIR). Prepared Microspheres were subjected to various physicochemical evaluations and in-vitro dissolution profile. The effects of different concentrations of polymer on Solubility enhancement were studied. The microspheres were compressed into tablets, and different tableting parameters were investigated. The dissolution profile of the tablets was also evaluated and compared with the marketed product. From the dissolution profile, it was observed that the carrier ratio of 3:1 of magnesium aluminum silicate to povidone K 30 exhibited higher dissolution rate than the other formulations.

Keywords

Solubility, Bicalutamide, Prostate Cancer, Microspheres, Tablets.
Subscription Login to verify subscription
User
Notifications
Font Size


  • Kadam N. R, Suvarna V., Microspheres: a brief review: Asian Journal of Biomedical and Pharmaceutical Sciences, 2015; 5(47), 13-19.

  • Kulkarni N. B, Wakte P. S, Naik J.B., Metformin hydrochloride microparticles for oral controlled release: effect of formulation variables: International Journal of Pharmacy and Pharmaceutical Sciences, 2013; 5(3), 135-144.

  • Ibrahim M. A, Shazly G. A, Badry M.E., Albendazole micro particles prepared by spray drying technique: improvement of drug dissolution, Tropical Journal of Pharmaceutical Research, 2014; 13(12), 1963-1970.

  • M. V. Srikanth, B. Janaki. Ram, D. Senthil. Rajan, G. Adinarayana, K. V. Ramanamurthy., Dissolution rate enhancement of Bicalutamide by adsorption process: African Journal of Pharmacy and Pharmacology, 2013; 7(21), 13571362.

  • Mudit Dixit, Ashwini G. Kini, Parthasarthi K. Kulkarni., Enhancing solubility and dissolution of celecoxib by spray drying using pluronicF-127: Indian Journal of Pharmaceutical Education and Research, 2011; 45(4), 346-352.

  • Mudit Dixit, R Narayana Charyulu, Anupama Shetty, Narayana Charyalu, Meghana Rao, Pallavi Bengre, Sharin Thomas., Enhancing solubility and dissolution of olanzapine by spray drying using β- cyclodextrin polymer: Journal of Applied Pharmaceutical Science, 2014; 4 (11), 81-86.

  • Puckhraj Chhaprel, Amit Talesara, Amit K Jain., Solubility enhancement of poorly water soluble drug using spray drying technique: International Journal of Pharmaceutical Studies and Research, 2012; 3(2),01-05.

  • B. Janaki Ram, D. Senthil Rajan, G. Adinarayana1 and K. V. Ramana Murthy., Dissolution rate enhancement of Bicalutamide by adsorption process; African Journal of Pharmacy and Pharmacology, 2013; 7(21), 1357-1362.


Abstract Views: 263

PDF Views: 0




  • Bicalutamide Tablets by Spray Dried Microspheres:An Approach to Enhance Solubility

Abstract Views: 263  |  PDF Views: 0

Authors

Rutuja R. Shah
Rajarambapu College of Pharmacy, Kasegaon, Tal. Walwa, Dist. Sangli, Maharashtra, India
Abhijeet Jadhav
Rajarambapu College of Pharmacy, Kasegaon, Tal. Walwa, Dist. Sangli, Maharashtra, India
Rohan R. Vakhariya
Rajarambapu College of Pharmacy, Kasegaon, Tal. Walwa, Dist. Sangli, Maharashtra, India

Abstract


The aim of the present study was to enhance the dissolution rate of poorly water soluble drug, Bicalutamide. Bicalutamide is an antiandrogen agent used in the treatment of prostate cancer. To improve the dissolution rate of the drug, hydrophilic carriers like povidone K30 was and methanol was used for preparing microspheres. Microspheres of Bicalutamide were prepared by spray drying technique by using povidone K 30 at different concentrations. The microspheres were evaluated for drug release profile. The compatibility was studied by Fourier Transforms Infrared spectroscopy (FTIR). Prepared Microspheres were subjected to various physicochemical evaluations and in-vitro dissolution profile. The effects of different concentrations of polymer on Solubility enhancement were studied. The microspheres were compressed into tablets, and different tableting parameters were investigated. The dissolution profile of the tablets was also evaluated and compared with the marketed product. From the dissolution profile, it was observed that the carrier ratio of 3:1 of magnesium aluminum silicate to povidone K 30 exhibited higher dissolution rate than the other formulations.

Keywords


Solubility, Bicalutamide, Prostate Cancer, Microspheres, Tablets.

References