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Formulation and Evaluation of Floating Matrix Tablets of Acyclovir using 32 Factorial Design
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Floating Drug Delivery Systems (FDDS) have a bulk density lower than gastric fluids and thus remain buoyant in the stomach for a prolonged period of time, without affecting the gastric emptying rate. While the system is floating on the gastric contents, the drug is released slowly at a desired rate from the system. These floating tablets mainly prepared for reduction of lag time and release the drug up to 12 hours and may also increase the bioavailability of the drugs by utilizing the drug to full extent avoiding unnecessary frequency of dosing. The study included formulation of floating tablets using polymers like Hydroxy propyl methyl cellulose K15M, PVP K30, Sodium bicarbonate, Xanthan-Gum, Guar-gum and microcrystalline cellulose as matrix forming agents. The tablets were directly compressed using Lab Press multi station rotary punching machine. FTIR and DSC-TGA studies conformed that there was no incompatibility between the polymers and the drug. Tablet preformulation parameters were within the Pharmacopoeias limit. Tablet showed zero lag time, continuance of buoyancy for >12 h. In vivo X-ray studies depicted that tablets continued to float in the GIT for 12 h. The in-vitro drug release pattern of Acyclovir floating tablets was fitted to different kinetic models which showed highest regression for zero order kinetics with Koresmeyer-peppasand most of the formulations followed Nonfickian diffusion.
Keywords
Acyclovi, Floating Drug Delivery System, HPMC, PVP K30, Xanthan-Gum, Guar-Gum, Matrix Devices, Gastroretentive Dosage Forms.
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- Moffat, A. C, Osselton, M. D, Widdop, B. Clarke’s Analysis of Drugs and Poisons. Pharma ceutical Press, London, 2004 2(3), 582.
- Sweetman, S. C. Martindale. Pharmaceutical Press, London, 2005, (34), 626.
- Gisbold‟ s Willson. Text Book of Organic Medicinal and Pharmaceutical Chemistry, Lippincott Williams and Wilkins, New York. London. 2004, (11) 372.
- Tripathi KD, Essential of Medical Pharmacology, Jaypee Brothers, Medical, Publisher, (P) LTD, New Delhi. 2008, (6) 767.
- Mridanga R.R, Bose S.K. and Sengupta K. Design, Development and in vitro evolution of directly compressed sustained release matrix tablet of famotidine. Research J. Pharm and Tech., 2008, 1(3): 175-178.
- Ajay B, Dinesh KP, Pradeep S. Studies on formulation and evaluation of floating tablets ofciprofloxacin. Int J Compren Pharma. 2010; 5(2): 1-3.
- Rocca JG, Omidian H, Shah K. Progress in Gastro retentive drug delivery system, Drug Delivery Oral. Pharm.Tech. 2003; 152–156.
- M, Zia H, Rhodes T. Design and testing in vitro of a bioadhesive and floatingdrugdelivery system for oral application. Int J Pharm. 1994; 105(1): 65-70.
- Sheth PR, Tossounian J. The hydrodynamically balanced system (HBS): a novel drug delivery system for oral use. Drug Dev. Ind. Pharm. 1994; 20: 313–339.
- Krunal PM, Biswajit B, Nabin K, Janki P. Preparation and evaluation of gastro retentivefloating tablets of mebendazole. Int J Curr Pharma Res. 2011; 3(1): 63-65.
- Sheth PR, Tossounian J. The hydrodynamically balanced system (HBS): a novel drug delivery system for oral use. Drug Dev. Ind. Pharm. 1994; 20: 313–339.
- Jadhav MN, Shanmugam S, Sundaramoorthy K, Ayyappan T, Vetrichelvan T.Formulation and in-vitro evaluation of gastro retentive floating matrix tablets of famotidine. Int J Pharma and Bio Sci, 2010; 4(1): 548-58.
- Friend DR. Oral delivery: A new approach to dosage forms. Pharmaceutical News 2002; 9: 375-80.
- Chein YW. Oral Drug Delivery and Delivery systems. In, Novel drug delivery Systems, Marcel Dekker, Inc, New York, 1992, 50(4), 139-177.
- Kavitha K, Puneeth KP, Tamizh MT. Development and evaluation of rosiglitazone maleatefloating tablets using natural gums. IJPT Res. 2010; 2(3): 1662-66.
- Orazio Luca Strusi, Gaia Colombo, Pedro Barata, Paolo Colombo. Module assemblage technology for floating systems: In vitro flotation and in vivo gastro-retention. J Control release; 2008, 129(3), 188-192.
- Gambhire MN, Ambade KW, Kurmi SD, Kadam VJ, Jadhav KR., Development and invitro evaluation of an oral floating matrix tablet formulation of Diltiazem hydrochloride, AAPS Pharm Sci Tech, 2007; 8(3): E 73.
- Patel SS, Ray S, Thakur RS., Formulation and evaluation of floating drug delivery system containing Clarithromycin for Helicobacter pylori, Acta Pol Pharm, 2006; 63(1): 53-61.
- Jaimini M, Rana AC, Tanwar YS., Formulation and evaluation of Famotidine floating tablets, Curr Drug Deliv. 2007; 4(1): 51-5.
- Thahera PD, Ashok, Latha K, Shailaja T, Nyamathulla S, UhumwanghoMU,Formulation and evaluation of Norfloxacin gastroretentive drug delivery systems using natural polymers, International current pharmaceutical journal, 2012; 1(7): 155-164.
- Patel Ishvar C, Hariprasnna RC, Mohan V Kodli, Patel vishal A, Pentewar Ram P,Formulation and evaluation of floating matrix tablets of Ketorolac tromethamine, IJPI’S Journal of pharmaceutics and Cosmetology, 2011; 2: 7.
- Gohel MC, Mehta PR, Dave PK, Bariya NH. More relevant dissolution method for evaluation of PDDS. Dissolution technol, 2005; 11: 22‐5.
- Swarna Kamala Chinthala CH, Srinivas Reddy Kota K, Hadassah M, HepsibhaMetilda E,Sridevi S, Fomulation and evaluation of gastroretentive floating tablets of Gabapentin using Effervescent technology, Int J Pharm Biomed Res 2012; 3(4): 202-208.
- Patel Sanjay S, Ray S. and Thakur R. S. Formualtion and evaluation of floating drug delivery system containing clarithromycin for Helicobacter Pylori. Acta Pol Pharma Dr Res, 2006, 63(1) 53-61.
- B, Dinesh KP, Pradeep S. Studies on formulation and evaluation of floating tablets ofciprofloxacin. Int J Compren Pharma. 2010; 5(2): 1-3.
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