Research Journal of Pharmaceutical Dosage Form and Technology

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Development and Optimization of Orodispersible Tablets of Serotonin Hydrochloride


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1 Pharmacy Institute, Noida Institute of Engineering and Technology, Noida, UP, India
     

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In present study, the orodispersible tablets of Serotonin Hydrochloride were prepared by direct compression technique using microcrystalline cellulose (MCC) as direct compressible diluents. Superdisintegrants such as Croscarmellulose sodium (CCS) Sodium starch glycolate (SSG), and Crospovidone were used. Method: Using different concentrations of superdisintegrants seven formulations were made and further investigated .The prepared powder mixtures were subjected to both pre and post compression evaluation parameters including tablet hardness, friability, disintegration time and in vitro drug release. Results: The pre-compression studies revealed that all formulations were found to be of good flowability. Tablet hardness and friability revealed good mechanical strength. Conclusion: All the tablets exhibited acceptable properties. According to the present study, it was found that tablets of batch F4 (blend containing CCS and crospovidone (15mg) showed better disintegrating property as well as % drug release (98.78% within 40 min).

Keywords

Orodispersible Tablet, Serotonin Hydrochloride, Superdisintegrants.
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  • Development and Optimization of Orodispersible Tablets of Serotonin Hydrochloride

Abstract Views: 263  |  PDF Views: 1

Authors

Pratik Swarup Das
Pharmacy Institute, Noida Institute of Engineering and Technology, Noida, UP, India
Puja Saha
Pharmacy Institute, Noida Institute of Engineering and Technology, Noida, UP, India

Abstract


In present study, the orodispersible tablets of Serotonin Hydrochloride were prepared by direct compression technique using microcrystalline cellulose (MCC) as direct compressible diluents. Superdisintegrants such as Croscarmellulose sodium (CCS) Sodium starch glycolate (SSG), and Crospovidone were used. Method: Using different concentrations of superdisintegrants seven formulations were made and further investigated .The prepared powder mixtures were subjected to both pre and post compression evaluation parameters including tablet hardness, friability, disintegration time and in vitro drug release. Results: The pre-compression studies revealed that all formulations were found to be of good flowability. Tablet hardness and friability revealed good mechanical strength. Conclusion: All the tablets exhibited acceptable properties. According to the present study, it was found that tablets of batch F4 (blend containing CCS and crospovidone (15mg) showed better disintegrating property as well as % drug release (98.78% within 40 min).

Keywords


Orodispersible Tablet, Serotonin Hydrochloride, Superdisintegrants.

References