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Development and Evaluation of Nanosuspension of Albendazole by Nanoprecipitation


Affiliations
1 Department of Pharmaceutics, Loknete Dr. J. D. Pawar College of Pharmacy, Manur, Tal. Kalwan – 423501, Dist.- Nashik, (MH), India
     

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The nanosuspension is one of the technology that can enhance the solubility of the poorly soluble drugs. It is an fine dispersion of the equal sized solid particles in an aqueous vehicle. The current objective of this work is to develop and evaluate nanosuspension of Albendazole, a poorly water-soluble anthelmintic drug, to enhance the solubility as well as the dissolution. The nanosuspension were formulated by nanoprecipitation with ultrasonication method using formic acid as solvent and water as anti-solvent. The formulated nanosuspensions were evaluated for particle size, drug entrapment efficiency, total drug content and the saturation solubility studies. In this study nine batches were formulated by using two different polymers that are PVP K-30 and Poloxamer 407 and as a surfactant SLS in which the concentration of the polymers was varied. The results of thepre formulation studies that are melting point 210-212oC, UV spectroscopic and FTIR studies proved that the drug was pure. The nanoparticles of Albendazole showed particle size in range of 0.005-0.020m. On the basis of the total drug content and drug entrapment efficiency formulation F7 showed the excellent results.

Keywords

Nanosuspension, Albendazole, Polymers, Nanoprecipitation, Particle Size, Solubility.
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  • Development and Evaluation of Nanosuspension of Albendazole by Nanoprecipitation

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Authors

Dode Raj H.
Department of Pharmaceutics, Loknete Dr. J. D. Pawar College of Pharmacy, Manur, Tal. Kalwan – 423501, Dist.- Nashik, (MH), India
Surawase Rajendra K.
Department of Pharmaceutics, Loknete Dr. J. D. Pawar College of Pharmacy, Manur, Tal. Kalwan – 423501, Dist.- Nashik, (MH), India

Abstract


The nanosuspension is one of the technology that can enhance the solubility of the poorly soluble drugs. It is an fine dispersion of the equal sized solid particles in an aqueous vehicle. The current objective of this work is to develop and evaluate nanosuspension of Albendazole, a poorly water-soluble anthelmintic drug, to enhance the solubility as well as the dissolution. The nanosuspension were formulated by nanoprecipitation with ultrasonication method using formic acid as solvent and water as anti-solvent. The formulated nanosuspensions were evaluated for particle size, drug entrapment efficiency, total drug content and the saturation solubility studies. In this study nine batches were formulated by using two different polymers that are PVP K-30 and Poloxamer 407 and as a surfactant SLS in which the concentration of the polymers was varied. The results of thepre formulation studies that are melting point 210-212oC, UV spectroscopic and FTIR studies proved that the drug was pure. The nanoparticles of Albendazole showed particle size in range of 0.005-0.020m. On the basis of the total drug content and drug entrapment efficiency formulation F7 showed the excellent results.

Keywords


Nanosuspension, Albendazole, Polymers, Nanoprecipitation, Particle Size, Solubility.

References