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Formulation and Evaluation of Captopril Sustained Release Pellet Containing Tablet by Fluidized Bed Processing
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A novel compression of coated pellets formulation of captopril was developed in order to improve the efficacy of antihypertensive therapy considering the half-life of drug. The sustained release pellets containing tablet were prepared by using 32 factorial design by employing 2 polymers i.e., HPMC k4M and eudragit RS 30D at 3 levels. As captopril having short half-life (2 hrs) there is need to formulate the modified release formulation. sustained release pellets containing tablet is the best approach to reduce the dose frequency of captopril tablet, by using the single polymer (eudragit RS 30D). The release retardant layer over a drug loaded pellets was achieved by 3% eudragit RS 30D polymer solution by using fluidized bed processor and then the pellets were mixed with otherexcipients and compress into the tablets and it showed the good sustained release pattern.
Keywords
Captopril, Sustained release, fluidized bed processor, eudragit RS 30D, HPMC k4M.
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