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An Updated Review on Solid Lipid Nanoparticles


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1 Department of Pharmaceutics, P.R. Pote Patil of College of Pharmacy, Kathora road, Amravati – 444604, Maharashtra, India
     

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The aims of review are the latest research development of the lipid based carriers according to the recent relevant literatures. Each preparation of the lipid based Nanoparticles (SLMs) have advantages and disadvantages. The SLMs is an excellent drug delivery system and has broad prospects in the pharmaceutical field. This review discusses the advantages, therapeutic application of SLMs, various techniques of preparation, and different routes of administration, material use and characterization of solid lipid Nanoparticles.

Keywords

SLM, Production Technique, Lipid Based Carrier, Pharmaceutical Application.
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  • Sachin J, Gupta NV. Solid lipid nanoparticles–preparation, applications, characterization, uses in various cancer therapies: a review. Research Journal of Pharmacy and Technology. 2013;6(8):825-37.
  • Malviya VR, Pande SD, Bobade NN. Preparation and Evaluation of Sustained Release Beads of Zolmitriptan Hydrochloride. Research Journal of Pharmacy and Technology. 2019;12(12):5972-6.
  • Malviya V, Manekar S. Design, development and evaluation of aceclofenac and curcumin agglomerates by Crystallo CoAgglomeration technique. Evaluation. 2021 Mar 1;1(1):1.
  • Mulla JA, Suresh S, Khazi IA. Formulation, characterization and in vitro evaluation of methotrexate solid lipid nanoparticles. Research Journal of Pharmacy and Technology. 2009;2(4):685-9.
  • Nachammai K, Nair KG, Ramaiyan Velmurugan SK. Sustained– Release study on Mefenamic acid and Mosapride loaded solid lipid Nanoparticles: In vitro Characterization. Research Journal of Pharmacy and Technology. 2020 Nov 13;13(11):5391-5.
  • Gholse YN, Yeole MP. Microencapsulation for the therapeutic delivery of Proteins and other drugs: Update and future challenges. Research Journal of Pharmacy and Technology. 2013;6(5):465-76.
  • Samal RP, Sahu PK. Formulation and evaluation of solid lipid nanoparticle of felbamate for improved drug delivery. Research Journal of Pharmacy and Technology. 2021;14(1):285-8.
  • Patel D, Prajapati ST, Patel CN, Patel J, Savan V. A Review on Insoluble Drug Delivery Technology. Research Journal of Pharmacy and Technology. 2010;3(2):333-8.
  • Dhiman S, Singh TG, Anand S, Yadav P. Formulation and Evaluation of Solid Lipid Nanoparticles for controlled delivery of Zidovudine. Research Journal of Pharmacy and Technology. 2021 May 26;14(5):2548-56.
  • Veni DK, Gupta NV. Quality by Design approach in the development of Solid Lipid Nanoparticles of Linagliptin. Research Journal of Pharmacy and Technology. 2019;12(9):4454-62.
  • Malviya V, Thakur Y, Gudadhe SS, Tawar M. Formulation and evaluation of natural gum based fast dissolving tablet of Meclizine hydrochloride by using 3 factorial design 2. Asian Journal of Pharmacy and Pharmacology. 2020;6(2):94-100.
  • Hou D, Xie C, Huang K, Zhu C. The production and characteristics of solid lipid nanoparticles (SLNs). Biomaterials. 2003 May 1;24(10):1781-5.
  • Mehnert W, Mäder K. Solid lipid nanoparticles: production, characterization and applications. Advanced drug delivery reviews. 2012 Dec 1;64:83-101.
  • Müller RH, Mäder K, Gohla S. Solid lipid nanoparticles (SLN) for controlled drug delivery–a review of the state of the art. European journal of pharmaceutics and biopharmaceutics. 2000 Jul 3;50(1):161-77.
  • Malviya VR, Pande SD. Road CKN. Preparation ad Evaluation of Zolmitriptan Hydrochloride Lozenge. J Pharma Res. 2019;8(8):624-9.
  • Malviya V, Ladhake V, Gajbiye K, Satao J, Tawar M. Design and Characterization of Phase Transition System of Zolmitriptan Hydrochloride for Nasal Drug Delivery System. International Journal of Pharmaceutical Sciences and Nanotechnology. 2020 May 31;13(3):4942-51.
  • Üner M, Yener G. Importance of solid lipid nanoparticles (SLN) in various administration routes and future perspectives. International journal of nanomedicine. 2007 Sep;2(3):289.
  • Morel S, Ugazio E, Cavalli R, Gasco MR. Thymopentin in solid lipid nanoparticles. International journal of pharmaceutics. 1996 Apr 30;132(1-2):259-61.
  • Malviya V. Preparation and Evaluation of Emulsomes as a Drug Delivery System for Bifonazole. Indian Journal of Pharmaceutical Education and Research. 2021 Jan 1;55(1):86-94.
  • Naseri N, Valizadeh H, Zakeri-Milani P. Solid lipid nanoparticles and nanostructured lipid carriers: structure, preparation and application. Advanced pharmaceutical bulletin. 2015 Sep;5(3):305.
  • Tiyaboonchai W, Tungpradit W, Plianbangchang P. Formulation and characterization of curcuminoids loaded solid lipid nanoparticles. International Journal of Pharmaceutics. 2007 Jun 7;337(1-2):299-306.
  • Malviya VR, Tawar MG. Preparation and Evaluation of Oral Dispersible Strips of Teneligliptin Hydrobromide for Treatment of Diabetes Mellitus. International Journal of Pharmaceutical Sciences and Nanotechnology. 2020 Jan 31;13(1):4745-52.
  • zur Mühlen A, Schwarz C, Mehnert W. Solid lipid nanoparticles (SLN) for controlled drug delivery–drug release and release mechanism. European journal of pharmaceutics and biopharmaceutics. 1998 Mar 1;45(2):149-55.
  • Almeida AJ, Souto E. Solid lipid nanoparticles as a drug delivery system for peptides and proteins. Advanced drug delivery reviews. 2007 Jul 10;59(6):478-90.

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  • An Updated Review on Solid Lipid Nanoparticles

Abstract Views: 135  |  PDF Views: 0

Authors

Aman Vyawahare
Department of Pharmaceutics, P.R. Pote Patil of College of Pharmacy, Kathora road, Amravati – 444604, Maharashtra, India
Nawaz Hakam
Department of Pharmaceutics, P.R. Pote Patil of College of Pharmacy, Kathora road, Amravati – 444604, Maharashtra, India
Kalpak Gajbhiye
Department of Pharmaceutics, P.R. Pote Patil of College of Pharmacy, Kathora road, Amravati – 444604, Maharashtra, India
Swanand Patharkar
Department of Pharmaceutics, P.R. Pote Patil of College of Pharmacy, Kathora road, Amravati – 444604, Maharashtra, India
Faizan Dosani
Department of Pharmaceutics, P.R. Pote Patil of College of Pharmacy, Kathora road, Amravati – 444604, Maharashtra, India

Abstract


The aims of review are the latest research development of the lipid based carriers according to the recent relevant literatures. Each preparation of the lipid based Nanoparticles (SLMs) have advantages and disadvantages. The SLMs is an excellent drug delivery system and has broad prospects in the pharmaceutical field. This review discusses the advantages, therapeutic application of SLMs, various techniques of preparation, and different routes of administration, material use and characterization of solid lipid Nanoparticles.

Keywords


SLM, Production Technique, Lipid Based Carrier, Pharmaceutical Application.

References