Open Access Open Access  Restricted Access Subscription Access
Open Access Open Access Open Access  Restricted Access Restricted Access Subscription Access

Herbal extracts in Novel Drug Delivery System: A Magical Combo: A Brief Review


Affiliations
1 Sigma Institute of Pharmacy, Ajwa Nimeta Road Vadodara, Gujrat, 390019,, India
     

   Subscribe/Renew Journal


Novel drug delivery system is a system which overcomes out the limitation of the herbal or traditional drug delivery system. The novel drug delivery technology used in the herbal plant based medicine boost up the efficacy and decreasing the side effect of herbal drugs. Drug delivery system of herbal medicine is an ancient technique used by our ancestors for curing and recovering. Due to the introduction of new allopathic and homeopathic medicine herbal system become out-of-date resulting in reducing efficacy of the drug. Herbal medicines improved by novel drug delivery system become able to combat more serious disease easily. Due to lack of scientific justification and research development of herbal drug Novel formulation growth was Because of improper standardization, extraction, identification of individual drug, complex Polyherbal system etc. Thisproblem becomes can be solved by the application of the Modern phyto-pharmaceutical research which can also help for improved pharmacokinetics of the herbal medicines and better understanding of mechanism of action. The incorporation of NDDS such as nanoparticles, microemulsions, matrix systems, liposomes, solid lipid nanoparticle, solid dispersions, etc. can also be useful for site specific drug delivery.

Keywords

Novel drug delivery system, Solid lipid nanoparticle, Solid dispersions.
Subscription Login to verify subscription
User
Notifications
Font Size


  • Herbal medicines today and the roots of modern pharmacology. [accessed on 2021 Jul 09];Ann Intern Med. 2001 135:594–600 .
  • Smith A. The benefits of natural medicine. [Accessed on 2021 Jul 09].
  • Parakh SR, Gothoskar AV. Review of mouth dissolving tablet technologies. Pharmaceutical Technology. Duluth, MN: Advanstar Communications; 2003. P. 47-52.
  • Sterer N, Nuas S, Mizrahi B, Goldenberg C, Weiss EI, Domb A, et al. Oral malodor reduction by a palatal mucoadhesive tablet containing herbal formulation. J Dent 2008;36:535-9.11.
  • C. Karuppusamy, and P. Venkatesan, Role of Nanoparticles in Drug Delivery System: A Comprehensive review, Journal of Pharmaceutical Science and Research. Vol. 9(3), 2017, 318-325
  • Saba Hasan, A Review on Nanoparticles: Their Synthesis and Types, Research Journal of Recent Sciences, Vol. 4(ISC-2014), 9- 11 (2015)
  • Brigger I, Dubernet C, Couvreur P. Nanoparticles in cancer therapy and diagnosis. Adv Drug Deliv Rev 2002;54:631-51.
  • Song YM, Ping QN, Wu ZH. Preparation of silybinnano emulsion and its pharmacokinetics in rabbits. J Chin Pharm Univ 2005;5:427-31.
  • Walve JR, Bakliwal SR, Rane BR, Pawar SP. Transfersomes: A surrogated carrier for transdermal drug delivery system. Int J ApplBiol Pharm Technol 2011;2:204-13.
  • Nikita R. Nikam, Priyanka R. Patil, R. R. Vakhariya, C. S. Magdum. Liposomes: A Novel Drug Delivery System: An Overview. Asian J. Pharm. Res. 2020; 10(1): 23-28.
  • Dattatraya M. Shinkar, Pinak S. Paralkar, R.B. Saudagar. An Overview on Trends and Developments in Liposome – as Drug Delivery System. Asian J. Pharm. Tech. 2015; 5(4): 231-237
  • (Szebeni J, and Development in Pharmacy and Life Sciences, 2013; 2(2): 285-292.D, Weinstein J.N, Inhibition of HIV-1 inmonocyte/macrophage cultures by 2I,3I-dideoxycytidine-5Itriphosphate, free and in liposomes, AIDS Res. Hum. Retroviruses 1990 ;6 :691–702.)
  • Manach C, Scalbert A, Morand C. Polyphenols: Food sources and bioavailability, Am J ClinNutr 2004; 79:727–47.
  • K. Aizawa, C. Liu, S. Tang, et al. Tobacco carcinogen induces both lung cancer and non-alcoholic steatohepatitis and hepatocellular carcinomas in ferrets which can be attenuated by lycopene supplementation. Int J Cancer, 139 (2016), pp. 1171- 1181
  • Abhishek Garg, SharadVisht, Pramod Kumar Sharma and Nitin Kumar, Formulation, Characterization and Application on Nanoparticle: A Review, Pelagia Research Library, Der Pharmacia Sinica, 2011, 2 (2): 17-26
  • Sarika V. Khandbahale, R. B. Saudagar. Nanoparticle- A review. Asian J. Pharm. Res. 2017;7(3): 162-172.
  • R, Roy chowdhury S. Implementing personalized cancer genomics in clinical trials. Nat Rev Drug Discov.2013;12:358– 369.
  • M. Zhang, E.G. Liu, Y.N. Cui, Y.Z. Huang, Nanotechnologybased combination therapy for overcoming multidrug-resistant cancer. Cancer Biol. Med. 14, 212–227 (2017).
  • Mundada AS, Formulation and evaluation of Coprocessed excipient for Mouth dissolving formulation, international journal of drug development and research, 2006.
  • Deepak P, Dharmesh S. Cubosomes: A Sustained Drug Delivery Carrier. Asian J. Res. Pharm. Sci. 2011, 1(3): 59-62.
  • Mahawar S. Development and Characterization of Docetaxel Encapsulated pH-Sensitive Liposomes for Cancer Therapy. Research J. Pharma. Dosage Forms and Tech. 2013; 5(3): 151-160.
  • Urvi S, Dhiren D, Bhavin P, Patel U and Shah R. Overview of cubosomes: A Nanoparticle. In. J of Ph. And Integ. Life Sci., 2013, 1(5): 36-47.
  • C.C. Wang, L.C. Liu, H.L. Cao, W. Zhang, Intracellular GSHactivatablegalactoside supramolecular photosensitizers for targeted photodynamic therapy and chemotherapy. J. Control. Release 259, E135–E136 (2017).
  • H.J. Hsu, J. Bugno, S.R. Lee, S. Hong, Dendrimer-based nanocarriers: a versatile platform for drug delivery. Wires Nanomed. Nanobi. 9, e1409 (2017).
  • Y.K. Li, M. Fang, J. Zhang, J. Wang, Y. Song et al., Hydrogel dual delivered celecoxib and anti-PD-1 synergistically improve antitumor immunity. Oncoimmunology 5, 1074374 (2016).
  • P.F. Zhao, Y.H. Wang, X.J. Kang, A.H. Wu,W.M. Yin et al., Dual-targeting biomimetic delivery for anti-glioma activity via remodeling the tumor microenvironment and directing macrophagemediated immunotherapy. Chem. Sci. 9, 2674–2689 (2018).

Abstract Views: 76

PDF Views: 0




  • Herbal extracts in Novel Drug Delivery System: A Magical Combo: A Brief Review

Abstract Views: 76  |  PDF Views: 0

Authors

Sheetal Sharma
Sigma Institute of Pharmacy, Ajwa Nimeta Road Vadodara, Gujrat, 390019,, India
Jigar Vyas
Sigma Institute of Pharmacy, Ajwa Nimeta Road Vadodara, Gujrat, 390019,, India
Umesh Upadhyay
Sigma Institute of Pharmacy, Ajwa Nimeta Road Vadodara, Gujrat, 390019,, India

Abstract


Novel drug delivery system is a system which overcomes out the limitation of the herbal or traditional drug delivery system. The novel drug delivery technology used in the herbal plant based medicine boost up the efficacy and decreasing the side effect of herbal drugs. Drug delivery system of herbal medicine is an ancient technique used by our ancestors for curing and recovering. Due to the introduction of new allopathic and homeopathic medicine herbal system become out-of-date resulting in reducing efficacy of the drug. Herbal medicines improved by novel drug delivery system become able to combat more serious disease easily. Due to lack of scientific justification and research development of herbal drug Novel formulation growth was Because of improper standardization, extraction, identification of individual drug, complex Polyherbal system etc. Thisproblem becomes can be solved by the application of the Modern phyto-pharmaceutical research which can also help for improved pharmacokinetics of the herbal medicines and better understanding of mechanism of action. The incorporation of NDDS such as nanoparticles, microemulsions, matrix systems, liposomes, solid lipid nanoparticle, solid dispersions, etc. can also be useful for site specific drug delivery.

Keywords


Novel drug delivery system, Solid lipid nanoparticle, Solid dispersions.

References