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Design and Characterization of Sustained Released Alginate Beads of Meclizine Hydrochloride
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The objective of present study was to prepare alginate beads of antihistamine meclizine hydrochloride for sustain release action. The alginate beads were prepared by employing sodium alginate as a polymer with sodium carboxymethyl cellulose and chitosan hydrochloride as release retardant. The method of preparation employed was ionotropic gelation. The prepared beads were seen having the drug release rate of 98.34% of A4 batch and 99.02% of B4 batch in the time period of 12hrs. The maximum percent drug content of 94.72±0.06% was found in A4 batch. From the results it can be seen that A4 batch was found to be optimum as it was having maximum drug content and maximum amount of drug release in the predicted time period of 12hrs. Themicrobeads of meclizine hydrochloride by using ionotropic gelation method were prepared successfully employing various polymers in different concentrations. The prepared microbeads can be a better alternative than various other sustained release dosages forms.
Keywords
Meclizine hydrochloride, Ionotropic Gelation, Anti-Histamine, Microbeads, Antiemetics.
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- Sivakumar R, Narayanan N, Rajendran NN. Bioadhesive Microbeads of Ketoprofen for Controlled and Site Specific Delivery. Research Journal of Pharmacy and Technology. 2011; 4(3): 385-8.
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- Masareddy RS, Rananaware SD, Patil BR. Preparation and Characterization of Rabeprazole Gastroretentive Drug Delivery System by Ionotropic Gelation Technique. Research Journal of Pharmacy and Technology. 2010; 3(2): 526-9.
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- Jaiswal M, Lanjhiyana SK. Fabrication and Evaluations of Dual Crosslinked Mesalamine containing Pectin-Chitosan gel micro beads for controlled and targeted colon delivery. Research Journal of Pharmacy and Technology. 2018;11(11):4797-804.
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- Roy H, Balaiah S, Kumar TV. Design and In-vitro Evaluation of Cefuroxime axetil floating Microbeads for Treatment of acute Bacterial caused Chronic Bronchitis. Research Journal of Pharmacy and Technology. 2018;11(6):2276-82.
- Chauhan SB, Singh V, Chauhan R. Enteric coated Microbeads as a Potential Delivery System for improved probiotic effect of Lactobacillus rhamnosus GG. Research Journal of Pharmacy and Technology. 2019;12(12):6049-56.
- Chengaiah B, Alagusundaram M, Ramkanth S, Chetty CM. Self emulsifying drug delivery system: a novel approach for drug delivery. Research Journal of Pharmacy and Technology. 2011;4(2):175-81.
- Gnanaprakash K, Shekhar KB, Chetty C. A review on floating drug delivery system of H2 receptors. Research Journal of Pharmacy and Technology. 2011;4(4):502-9.
- Putney SD, Burke PA. Improving protein therapeutics with sustained-release formulations. Nature Biotechnology. 1998 Feb;16(2):153-7.
- Leroux JC, Allémann E, De Jaeghere F, Doelker E, Gurny R. Biodegradable nanoparticles—from sustained release formulations to improved site specific drug delivery. Journal of Controlled Release. 1996 May 1;39(2-3):339-50.
- Takahara J, Takayama K, Nagai T. Multi-objective simultaneous optimization technique based on an artificial neural network in sustained release formulations. Journal of Controlled Release. 1997 Nov 10;49(1):11-20.
- Lee HJ, Riley G, Johnson O, Cleland JL, Kim N, Charnis M, Bailey L, Duenas E, Shahzamani A, Marian M, Jones AJ. In vivo characterization of sustained-release formulations of human growth hormone. Journal of Pharmacology and Experimental Therapeutics. 1997 Jun 1;281(3):1431-9.
- Ankit B, Rathore RP, Tanwar YS, Gupta S, Bhaduka G. Oral sustained release dosage form: an opportunity to prolong the release of drug. IJARPB. 2013 Jan 1;3(1):7-14.
- Malviya V, Pande S. Development and Evaluation of Fast dissolving Film of Fluoxetine hydrochloride. Research Journal of Pharmacy and Technology. 2021 Oct 31;14(10):5345-50.
- Hilton AK, Deasy PB. In vitro and in vivo evaluation of an oral sustained-release floating dosage form of amoxycillin trihydrate. International Journal of Pharmaceutics. 1992 Oct 10;86(1):79-88.
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