Research Journal of Pharmaceutical Dosage Form and Technology

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Transferosome: A Vesicular Transdermal Delivery System for Enhanced Drug Permeation


Affiliations
1 Student, Department of Pharmaceutics, Shri. D.D. Vispute College of Pharmacy and Research Center, Panvel., India
2 Assistant Professor, Department of Pharmaceutics, Shri. D.D. Vispute College of Pharmacy and Research Center, Panvel., India
3 Principal, Department of Pharmacy, Shri. D.D. Vispute College of Pharmacy and Research Center, Panvel., India
     

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The barrier function of the skin limits transdermal medication delivery. Vesicular systems are one of the most contentious mechanisms for delivering active compounds transdermally. The discovery of elastic vesicles such transferosomes, ethosomes, cubosomes, phytosomes, and others reignited interest in creating transdermal delivery systems. Vesicular drug delivery systems are highly organised assemblies made up of one or more concentric bilayers that form when amphiphilic building units self-assemble in water. Because of their potential to localise drug activity at the site or organ of action while reducing its concentration at other places in the body, vesicular drug delivery systems are particularly significant for targeted drug delivery. The vesicular drug delivery system keeps drug activity at a specified rate, keeps drug levels in the body reasonably constant (zero order kinetics), and reduces unwanted side effects at the same time. It can also target medication delivery utilizing carriers or chemical derivatization to localise drug action in the affected tissue or organ. Vesicular drug delivery systems have been used to improve The therapeutic index, solubility, stability, and rapid degradation of a pharmacological molecule are all important factors to consider. As a result, a number of innovative vesicular drug delivery systems that allow drug targeting and prolonged or regulated drug release have been produced. This review will focus on diverse lipoidal and non-lipoidal vesicles, with a special emphasis on pharmaceutical targeting.

Keywords

Transdermal Drug Delivery, Vesicular Delivery, Transferosome, Method of preparation, Applications.
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  • Transferosome: A Vesicular Transdermal Delivery System for Enhanced Drug Permeation

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Authors

Snehal Arjun Kurhe
Student, Department of Pharmaceutics, Shri. D.D. Vispute College of Pharmacy and Research Center, Panvel., India
Kedar Bavaskar
Assistant Professor, Department of Pharmaceutics, Shri. D.D. Vispute College of Pharmacy and Research Center, Panvel., India
Ashish Jain
Principal, Department of Pharmacy, Shri. D.D. Vispute College of Pharmacy and Research Center, Panvel., India

Abstract


The barrier function of the skin limits transdermal medication delivery. Vesicular systems are one of the most contentious mechanisms for delivering active compounds transdermally. The discovery of elastic vesicles such transferosomes, ethosomes, cubosomes, phytosomes, and others reignited interest in creating transdermal delivery systems. Vesicular drug delivery systems are highly organised assemblies made up of one or more concentric bilayers that form when amphiphilic building units self-assemble in water. Because of their potential to localise drug activity at the site or organ of action while reducing its concentration at other places in the body, vesicular drug delivery systems are particularly significant for targeted drug delivery. The vesicular drug delivery system keeps drug activity at a specified rate, keeps drug levels in the body reasonably constant (zero order kinetics), and reduces unwanted side effects at the same time. It can also target medication delivery utilizing carriers or chemical derivatization to localise drug action in the affected tissue or organ. Vesicular drug delivery systems have been used to improve The therapeutic index, solubility, stability, and rapid degradation of a pharmacological molecule are all important factors to consider. As a result, a number of innovative vesicular drug delivery systems that allow drug targeting and prolonged or regulated drug release have been produced. This review will focus on diverse lipoidal and non-lipoidal vesicles, with a special emphasis on pharmaceutical targeting.

Keywords


Transdermal Drug Delivery, Vesicular Delivery, Transferosome, Method of preparation, Applications.

References