Research Journal of Pharmaceutical Dosage Form and Technology

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Approaches to Creating and Past Successful Attempts on Microspheres: A Primer for Aspiring Researchers


Affiliations
1 Department of Industrial Pharmacy, Raghavendra Institute of Pharmaceutical Education and Research (RIPER) - Autonomous, K.R. Palli Cross, Chiyyedu (P), Ananthapuramu - 515721, AP,, India
     

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The work was aimed at the gathering and projection of literature on microspheres. A targeted drug delivery system is intended to increase the concentration of medication in the areas of interest while reducing its concentration in the rest of the body. Thus, the drug is localized at the target site. It does not affect the surrounding tissues. Carriers have therefore proven to be a useful approach to drug delivery since the drug is coupled with a carrier particle such as microspheres, nanoparticles, liposomes, niosomes, and so on, that controls the release and absorption of the drug. A microsphere is a free-flowing powder consisting of proteins or synthetic polymers that are biodegradable in nature and, ideally, have a particle size of under 200 m. If it is modified, it is a reliable way to deliver the drug to the target site with high specificity and to maintain the desired concentration without unintended side effects. As a result of their long-term release, microspheres have been receiving a lot of attention, especially for their ability to target anticancer drugs to the tumor. By combining microspheres with a variety of other strategies, microspheres will have a key role in the delivery of pharmaceuticals, especially in diseased cell sorting, diagnostics, gene delivery, and safe, targeted, and effective in vivo delivery. This article will help research to get a quick reference to the past work done on microsphere dosage forms.

Keywords

Delivery, microspheres, release, review, target.
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  • Approaches to Creating and Past Successful Attempts on Microspheres: A Primer for Aspiring Researchers

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Authors

Kappala Sailaja
Department of Industrial Pharmacy, Raghavendra Institute of Pharmaceutical Education and Research (RIPER) - Autonomous, K.R. Palli Cross, Chiyyedu (P), Ananthapuramu - 515721, AP,, India
Hindustan Abdul Ahad,
Department of Industrial Pharmacy, Raghavendra Institute of Pharmaceutical Education and Research (RIPER) - Autonomous, K.R. Palli Cross, Chiyyedu (P), Ananthapuramu - 515721, AP,, India
Haranath Chinthaginjala
Department of Industrial Pharmacy, Raghavendra Institute of Pharmaceutical Education and Research (RIPER) - Autonomous, K.R. Palli Cross, Chiyyedu (P), Ananthapuramu - 515721, AP,, India
Renuka Gudisipalli
Department of Industrial Pharmacy, Raghavendra Institute of Pharmaceutical Education and Research (RIPER) - Autonomous, K.R. Palli Cross, Chiyyedu (P), Ananthapuramu - 515721, AP,, India
Sugali Indravath Rajyalakshmi
Department of Industrial Pharmacy, Raghavendra Institute of Pharmaceutical Education and Research (RIPER) - Autonomous, K.R. Palli Cross, Chiyyedu (P), Ananthapuramu - 515721, AP,, India
Yamuna Vagganagari
Department of Industrial Pharmacy, Raghavendra Institute of Pharmaceutical Education and Research (RIPER) - Autonomous, K.R. Palli Cross, Chiyyedu (P), Ananthapuramu - 515721, AP,, India

Abstract


The work was aimed at the gathering and projection of literature on microspheres. A targeted drug delivery system is intended to increase the concentration of medication in the areas of interest while reducing its concentration in the rest of the body. Thus, the drug is localized at the target site. It does not affect the surrounding tissues. Carriers have therefore proven to be a useful approach to drug delivery since the drug is coupled with a carrier particle such as microspheres, nanoparticles, liposomes, niosomes, and so on, that controls the release and absorption of the drug. A microsphere is a free-flowing powder consisting of proteins or synthetic polymers that are biodegradable in nature and, ideally, have a particle size of under 200 m. If it is modified, it is a reliable way to deliver the drug to the target site with high specificity and to maintain the desired concentration without unintended side effects. As a result of their long-term release, microspheres have been receiving a lot of attention, especially for their ability to target anticancer drugs to the tumor. By combining microspheres with a variety of other strategies, microspheres will have a key role in the delivery of pharmaceuticals, especially in diseased cell sorting, diagnostics, gene delivery, and safe, targeted, and effective in vivo delivery. This article will help research to get a quick reference to the past work done on microsphere dosage forms.

Keywords


Delivery, microspheres, release, review, target.

References