Research Journal of Pharmaceutical Dosage Form and Technology

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Natural Polymer Based Floating Matrix Tablets of Domperidone


Affiliations
1 Mallige College of Pharmacy, Bengaluru 560090, Karnataka,, India
2 Subtle Pharmaceutical Private limited, Bengaluru 560058, Karnataka, India., India
     

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Aim: This study is aimed to prepare floating matrix Domperidone Maleate tablets by using natural polymers. Materials and Methods: Domperidone maleate was formulated as floating matrix tablets to increase the gastric residence time. Natural polymers like xanthan gum, tragacanth, sodium alginate along with sodium bicarbonate, citric acid and HPMC were used to increase the buoyancy time and decrease the floating lag time. The compressed tablets were evaluated for various parameters like friability, hardness, uniformity of weight, uniformity of drug content, swelling index, bouncy time and in-vitro drug release. Results: The evaluated parameters were in compliance with the pharmacopoeial limits. The most successful formulation was F2, containing xanthan gum as polymer. The drug release was extended up to 10 h which was close to that oftheoretical release profile. Mathematical modelling of in-vitro dissolution data indicated the best-fit release kinetics was achieved with Zero order model with R2 values of 0.99. Conclusion: The prepared sustained release floating tablets of domperidone maleate could perform therapeutically better than that of conventional sustained release tablets with improved efficacy and better patient compliance.

Keywords

Domperidone maleate, Floating matrix tablet, Natural polymers, Swelling index, in-vitro drug release.
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  • Natural Polymer Based Floating Matrix Tablets of Domperidone

Abstract Views: 339  |  PDF Views: 0

Authors

Sheeba FR
Mallige College of Pharmacy, Bengaluru 560090, Karnataka,, India
Amar Sahani
Mallige College of Pharmacy, Bengaluru 560090, Karnataka,, India
Yogesh DB
Subtle Pharmaceutical Private limited, Bengaluru 560058, Karnataka, India., India

Abstract


Aim: This study is aimed to prepare floating matrix Domperidone Maleate tablets by using natural polymers. Materials and Methods: Domperidone maleate was formulated as floating matrix tablets to increase the gastric residence time. Natural polymers like xanthan gum, tragacanth, sodium alginate along with sodium bicarbonate, citric acid and HPMC were used to increase the buoyancy time and decrease the floating lag time. The compressed tablets were evaluated for various parameters like friability, hardness, uniformity of weight, uniformity of drug content, swelling index, bouncy time and in-vitro drug release. Results: The evaluated parameters were in compliance with the pharmacopoeial limits. The most successful formulation was F2, containing xanthan gum as polymer. The drug release was extended up to 10 h which was close to that oftheoretical release profile. Mathematical modelling of in-vitro dissolution data indicated the best-fit release kinetics was achieved with Zero order model with R2 values of 0.99. Conclusion: The prepared sustained release floating tablets of domperidone maleate could perform therapeutically better than that of conventional sustained release tablets with improved efficacy and better patient compliance.

Keywords


Domperidone maleate, Floating matrix tablet, Natural polymers, Swelling index, in-vitro drug release.

References