Research Journal of Pharmaceutical Dosage Form and Technology

Open Access Open Access  Restricted Access Subscription Access
Open Access Open Access Open Access  Restricted Access Restricted Access Subscription Access

Solubility Enhancement of Resveratrol by Effervescence Assisted Fusion Technique


Affiliations
1 Department of Pharmaceutics, P.R. Pote Patil College of Pharmacy, Amravati – 444604., India
     

   Subscribe/Renew Journal


The basic reason behind this study was to enhance the solubility rate of resveratrol which will finally enhance the dissolution i.e. the rate of drug release due to which the absorption of the drug will increase. The method applied here was effervescent assisted fusion technique. Various batches were prepared by employing water soluble carrier and sodium bicarbonate. The results obtained from the study revealed that the solubility of the drug can be increased up to 10 times than compared with the pure drug in various solvents i.e. phosphate buffer and distilled water. The compatibility study showed no interaction between drug and the excipient while the micromeretics property showed good flow property with good compressibility property. The percent yield of the dispersions prepared ranges between 79.20±0.28% - 89.38±0.25% while the drug release data showed a better rate of drug release than compared with the pure drug which ranges between 10.87% - 99.14%. The pure drug was having a drug release of less than 70% while the optimized batch F5 was having a drug release of more than 95% in the specific period of time. The XRD data showed that the drug’s crystalline structure was not hampered during the preparation while the SEM data revealed the surface shape of the pure drug which was tile shaped and the prepared dispersion was of flakes like formation. From the study it can be concluded that the methods employed in this study can be proven to be a excellent method for enhancing the solubility of the drug up to 10 folds.

Keywords

Resveratrol, Effervescent Assisted fusion technique, Solubility, Drug Release, Crystals.
Subscription Login to verify subscription
User
Notifications
Font Size


  • Malviya VR, Pande SD, Bobade NN. Preparation and evaluation of sustained release beads of zolmitriptan hydrochloride. Research Journal of Pharmacy and Technology. 2019 Dec 30;12(12):5972-6.

  • Chitlange SS, Pawbake GR, Pandkar SV, Wankhede SB. Formulation and evaluation of diacerein solid dispersion for solubility and dissolution rate enhancement. Research Journal of Pharmacy and Technology. 2011;4(6):932-7.

  • Malviya V, Thakur Y, Gudadhe SS, Tawar M. Formulation and evaluation of natural gum based fast dissolving tablet of Meclizine hydrochloride by using 3 factorial design 2. Asian Journal of Pharmacy and Pharmacology. 2020;6(2):94-100.

  • Sharma D, Soni M, Kumar S, Gupta GD. Solubility enhancement—eminent role in poorly soluble drugs. Research Journal of Pharmacy and Technology. 2009 Apr;2(2):220-4.

  • Malviya VR, Pande SD. Road CKN. Preparation ad Evaluation of Zolmitriptan Hydrochloride Lozenge. J Pharma Res. 2019;8(8):624-9.

  • Patil A, Desai BG, Shivakumar HN. Enhancement of Nateglinide Solubility and Dissolution Rate. Research Journal of Pharmacy and Technology. 2011;4(7):1159-64.

  • Malviya V, Ladhake V, Gajbiye K, Satao J, Tawar M. Design and characterization of phase transition system of zolmitriptan hydrochloride for nasal drug delivery system. International Journal of Pharmaceutical Sciences and Nanotechnology. 2020 May 31;13(3):4942-51.

  • Jagtap RS, Doijad RC, Mohite SK. Adsorption of nifedipine on porous calcium silicate for enhancement of solubility and dissolution rate. Research Journal of Pharmacy and Technology. 2019;12(3):1273-9.

  • Malviya VR, Tawar MG. Preparation and evaluation of oral dispersible strips of teneligliptin hydrobromide for treatment of diabetes mellitus. International Journal of Pharmaceutical Sciences and Nanotechnology. 2020 Jan 31;13(1):4745-52.

  • Srikanth MV, Babu GV, Sunil SA, Rao NS, Kumar KP, Murthy KV. Studies on the effect of hydrophilic carriers in the dissolution rate enhancement of poorly soluble drug, bicalutamide. Research Journal of Pharmacy and Technology. 2010;3(2):592-5.

  • Malviya V, Manekar S. Design, Development and Evaluation of Aceclofenac and Curcumin Agglomerates by Crystallo CoAgglomeration Technique. Research Journal of Pharmacy and Technology. 2021 Mar 1;14(3):1535-41.

  • Jadhav YL, Parashar B, Ostwal PP, Jain MS. Solid dispersion: Solubility enhancement for poorly water soluble drug. Research Journal of Pharmacy and Technology. 2012 Feb 1;5(2):190.

  • Yadav AV, Yadav VB. Improvement of Physicochemical properties of Mesalamine with Hydrophilic Carriers by Solid Dispersion (kneading) method. Research Journal of Pharmacy and Technology. 2008;1(4):422-5.

  • Gubbi S, Jarag R. Liquisolid technique for enhancement of dissolution properties of bromhexine hydrochloride. Research Journal of Pharmacy and Technology. 2009;2(2):382-6.

  • Malviya V. Preparation and Evaluation of Emulsomes as a Drug Delivery System for Bifonazole. Indian journal of pharmaceutical education and research. 2021 Jan 1;55(1):86-94.

  • Malviya V. Design and Characterization of Thermosensitive Mucoadhesive Nasal Gel for Meclizine Hydrochloride. International Journal of Pharmaceutical Sciences and Nanotechnology. 2022 Feb 28;15(1):5782-93.

  • Gubbi S, Jarag R. Liquisolid technique for enhancement of dissolution properties of bromhexine hydrochloride. Research Journal of Pharmacy and Technology. 2009;2(2):382-6.

  • Burange PJ, Tawar MG, Bairagi RA, Malviya VR, Sahu VK, Shewatkar SN, Sawarkar RA, Mamurkar RR. Synthesis of silver nanoparticles by using Aloe vera and Thuja orientalis leaves extract and their biological activity: a comprehensive review. Bulletin of the National Research Centre. 2021 Dec;45(1):1-3.

  • Duraivel S, Venkateswarlu V, Kumar AP, Gopinath H. Enhancement of dissolution rate of cefpodoxime proxetil by using solid dispersion and cogrinding approaches. Research Journal of Pharmacy and Technology. 2012;5(12):1552-62.

  • Malviya V, Pande S. Development and Evaluation of Fast dissolving Film of Fluoxetine hydrochloride. Research Journal of Pharmacy and Technology. 2021 Oct 31;14(10):5345-50.

  • Hajare AA, Kashid UT, Walekar P, Hajare PM. Enhancement of dissolution rate and formulation development of efavirenz capsule employing solid dispersion method. Research Journal of Pharmacy and Technology. 2013;6(1):10.

  • Malviya V, Burange P, Thakur Y, Tawar M. Enhancement of Solubility and Dissolution Rate of Atazanavir Sulfate by Nanocrystallization. Indian Journal of Pharmaceutical Education and Research. 2021 Jul 1;55(3):S672-80.

  • Jawahar N, Sureshkumar R, Venkatesh DN, Ganesh GN, Jubie S, Samanta MK, Suresh B. Polymorphism: A Dissolution Rate Enhancement Technique of Nitrendipine. Research Journal of Pharmacy and Technology. 2008;1(3):285-6.

  • Malviya, Vedanshu, Mukund Tawar, Prashant Burange, and Rahul Jodh. "A Brief Review on Resveratrol." (2022): 157-162.

  • Danki LS, Thube SS. Studies on the Effect of Ternary Complex Formation of Simvastatin: β-Cyclodextrin with Polyvinyl Pyrrolidone and Hydroxypropyl Methylcellulose. Research Journal of Pharmacy and Technology. 2010;3(4):1148-51.


Abstract Views: 441

PDF Views: 0




  • Solubility Enhancement of Resveratrol by Effervescence Assisted Fusion Technique

Abstract Views: 441  |  PDF Views: 0

Authors

Mukund Tawar
Department of Pharmaceutics, P.R. Pote Patil College of Pharmacy, Amravati – 444604., India
Kiran Raut
Department of Pharmaceutics, P.R. Pote Patil College of Pharmacy, Amravati – 444604., India
Reshma Chaudhary
Department of Pharmaceutics, P.R. Pote Patil College of Pharmacy, Amravati – 444604., India
Nikita Jain
Department of Pharmaceutics, P.R. Pote Patil College of Pharmacy, Amravati – 444604., India

Abstract


The basic reason behind this study was to enhance the solubility rate of resveratrol which will finally enhance the dissolution i.e. the rate of drug release due to which the absorption of the drug will increase. The method applied here was effervescent assisted fusion technique. Various batches were prepared by employing water soluble carrier and sodium bicarbonate. The results obtained from the study revealed that the solubility of the drug can be increased up to 10 times than compared with the pure drug in various solvents i.e. phosphate buffer and distilled water. The compatibility study showed no interaction between drug and the excipient while the micromeretics property showed good flow property with good compressibility property. The percent yield of the dispersions prepared ranges between 79.20±0.28% - 89.38±0.25% while the drug release data showed a better rate of drug release than compared with the pure drug which ranges between 10.87% - 99.14%. The pure drug was having a drug release of less than 70% while the optimized batch F5 was having a drug release of more than 95% in the specific period of time. The XRD data showed that the drug’s crystalline structure was not hampered during the preparation while the SEM data revealed the surface shape of the pure drug which was tile shaped and the prepared dispersion was of flakes like formation. From the study it can be concluded that the methods employed in this study can be proven to be a excellent method for enhancing the solubility of the drug up to 10 folds.

Keywords


Resveratrol, Effervescent Assisted fusion technique, Solubility, Drug Release, Crystals.

References