Research Journal of Pharmaceutical Dosage Form and Technology

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Development of Zinc Gluconate Vitamin C Effervescent Tablet for Immunity Improvement and Management of COVID-19


Affiliations
1 Department of Pharmaceutics, Loknete Dr. J. D. Pawar College of Pharmacy, Manur, Tal. Kalwan - 423501, Dist. Nashik, (MH), India
2 Department of Pharmaceutics, Loknete Dr. J. D. Pawar College of Pharmacy, Manur, Tal. Kalwan - 423501, Dist. Nashik, (MH)
     

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This look at aimed to increase the system of effervescent tablet containing zinc Gluconate and Ascorbic acid (vit c) combination to increase immunity and likely through reducing viral load and improving immunity of the patients. In this examine the formula turned into calculated exactly and then prepared by way of two distinct srtategies for compression and assessment. The flowability of powder and grannules turned into investigated effervescent tablet were produced by way of direct compression and wet granulation approach. The produced tablet have been then evaluated for appropriate hardness, friability ˂1%, effervescent time ˂ 3 minutes, solution PH ˂6, water content ˂ 0.5% and most beneficial content uniformity. The powder aggregate prepared for the direct compression technique had acceptable flowability however required a excessive compression force. Flowability and different physicochemical properties of this powder. Including compressibility and hardness have been progressed with the aid of granulation. The result of effervescent tablet produced by way of the moist granulation technique, which incorporate a higher percent of granulated content material have been higher than other method. The PVP-K30 binder solution is suitable to produced bubbling granules which are compressed into tablet, because of improvement in flowability and compactibility.

Keywords

Zinc Gluconate, Vitamin C, Effervescent tablet, Immunity, Wet granulation method
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  • Development of Zinc Gluconate Vitamin C Effervescent Tablet for Immunity Improvement and Management of COVID-19

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Authors

Bagul Mahesh B
Department of Pharmaceutics, Loknete Dr. J. D. Pawar College of Pharmacy, Manur, Tal. Kalwan - 423501, Dist. Nashik, (MH), India
Surawase Rajendra K.
Department of Pharmaceutics, Loknete Dr. J. D. Pawar College of Pharmacy, Manur, Tal. Kalwan - 423501, Dist. Nashik, (MH)

Abstract


This look at aimed to increase the system of effervescent tablet containing zinc Gluconate and Ascorbic acid (vit c) combination to increase immunity and likely through reducing viral load and improving immunity of the patients. In this examine the formula turned into calculated exactly and then prepared by way of two distinct srtategies for compression and assessment. The flowability of powder and grannules turned into investigated effervescent tablet were produced by way of direct compression and wet granulation approach. The produced tablet have been then evaluated for appropriate hardness, friability ˂1%, effervescent time ˂ 3 minutes, solution PH ˂6, water content ˂ 0.5% and most beneficial content uniformity. The powder aggregate prepared for the direct compression technique had acceptable flowability however required a excessive compression force. Flowability and different physicochemical properties of this powder. Including compressibility and hardness have been progressed with the aid of granulation. The result of effervescent tablet produced by way of the moist granulation technique, which incorporate a higher percent of granulated content material have been higher than other method. The PVP-K30 binder solution is suitable to produced bubbling granules which are compressed into tablet, because of improvement in flowability and compactibility.

Keywords


Zinc Gluconate, Vitamin C, Effervescent tablet, Immunity, Wet granulation method

References