Research Journal of Pharmaceutical Dosage Form and Technology

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Liquisolid Technique for Enhancing Dissolution Rate: A Review


Affiliations
1 Vidyabharti College of Pharmacy, Camp Road, Amravati, Maharashtra, 444602, India
2 Vidyabharti College of Pharmacy, Camp Road, Amravati, Maharashtra, 444602, India
     

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The bioavailability of many poorly water-soluble drugs is limited by their dissolution rates which are in turn controlled by the effective surface area present for dissolution Therapeutic effectiveness of a drug depends upon the bioavailability. Solubility is one of the important parameter to achieve desired concentration of drug in systemic circulation for pharmacological response to be shown. The enhancement of oral bioavailability of poorly water soluble drugs remains one of the most challenging aspects of drug development. A more recent technique, “Liquisolid technology” or “powdered solution technology” has been applied to prepare water-insoluble drugs into rapidrelease solid dosage forms. The technique is based upon the dissolving the insoluble drug in the nonvolatile solvent and admixture of drug loaded solutions with appropriate carrier and coating materials to convert into acceptably flowing and compressible powders.

Keywords

Insoluble Drug, Bioavailability, Liquisolid Technique.
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  • Liquisolid Technique for Enhancing Dissolution Rate: A Review

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Authors

A.D. Deshmukh
Vidyabharti College of Pharmacy, Camp Road, Amravati, Maharashtra, 444602, India
S.R. Wasankar
Vidyabharti College of Pharmacy, Camp Road, Amravati, Maharashtra, 444602, India
R.M. Burghate
Vidyabharti College of Pharmacy, Camp Road, Amravati, Maharashtra, 444602, India
M.A. Ughade
Vidyabharti College of Pharmacy, Camp Road, Amravati, Maharashtra, 444602, India

Abstract


The bioavailability of many poorly water-soluble drugs is limited by their dissolution rates which are in turn controlled by the effective surface area present for dissolution Therapeutic effectiveness of a drug depends upon the bioavailability. Solubility is one of the important parameter to achieve desired concentration of drug in systemic circulation for pharmacological response to be shown. The enhancement of oral bioavailability of poorly water soluble drugs remains one of the most challenging aspects of drug development. A more recent technique, “Liquisolid technology” or “powdered solution technology” has been applied to prepare water-insoluble drugs into rapidrelease solid dosage forms. The technique is based upon the dissolving the insoluble drug in the nonvolatile solvent and admixture of drug loaded solutions with appropriate carrier and coating materials to convert into acceptably flowing and compressible powders.

Keywords


Insoluble Drug, Bioavailability, Liquisolid Technique.

References