Research Journal of Pharmaceutical Dosage Form and Technology

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Novel Approaches for Delivery of Proteins and Peptides – A Review


Affiliations
1 Centre for Pharmaceutical Sciences, Institute of Science and Technology, Jawaharlal Nehru Technological University, Kukatpally, Hyderabad, India
     

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Peptides are short polymers of amino acids (usually less than or equal to 100) joined together by peptide bonds and comprise some of the basic components of human biological processes, including enzymes, hormones, and antibodies. The link between one amino acid residue and the next is known as a peptide bond. Proteins are typically much longer chains of (greater than 100) amino acids similarly linked by peptide bonds. These polypeptides and proteins play an important role in functioning of vital organs. They are involved in structural, signalling and enzymatic functions. A simple change in the protein structure can trigger functions, such as signalling, targeting, catalysis, catabolism, modification of circulation time in the body and immunogenicity. They are used for systemic treatment of certain disease. As the modern genomic and proteomic technology enables rapid screening of novel proteins and peptides as potential drug candidates, design of delivery systems for these biologics remains challenging especially to achieve site specific pharmacological actions. This article discusses the issues associated with targeted delivery of protein and peptide drugs.

Keywords

Peptides, Proteins, Drug Delivery, Site Specific, Genomic and Proteomic Technology, Targeted Delivery.
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  • Novel Approaches for Delivery of Proteins and Peptides – A Review

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Authors

M. Sunitha Reddy
Centre for Pharmaceutical Sciences, Institute of Science and Technology, Jawaharlal Nehru Technological University, Kukatpally, Hyderabad, India
Sama Mallikarjun Reddy
Centre for Pharmaceutical Sciences, Institute of Science and Technology, Jawaharlal Nehru Technological University, Kukatpally, Hyderabad, India
A. Mahesh Chandra
Centre for Pharmaceutical Sciences, Institute of Science and Technology, Jawaharlal Nehru Technological University, Kukatpally, Hyderabad, India
B. Sai Santhosh
Centre for Pharmaceutical Sciences, Institute of Science and Technology, Jawaharlal Nehru Technological University, Kukatpally, Hyderabad, India
Ch. Surekha
Centre for Pharmaceutical Sciences, Institute of Science and Technology, Jawaharlal Nehru Technological University, Kukatpally, Hyderabad, India
K. Naveen
Centre for Pharmaceutical Sciences, Institute of Science and Technology, Jawaharlal Nehru Technological University, Kukatpally, Hyderabad, India

Abstract


Peptides are short polymers of amino acids (usually less than or equal to 100) joined together by peptide bonds and comprise some of the basic components of human biological processes, including enzymes, hormones, and antibodies. The link between one amino acid residue and the next is known as a peptide bond. Proteins are typically much longer chains of (greater than 100) amino acids similarly linked by peptide bonds. These polypeptides and proteins play an important role in functioning of vital organs. They are involved in structural, signalling and enzymatic functions. A simple change in the protein structure can trigger functions, such as signalling, targeting, catalysis, catabolism, modification of circulation time in the body and immunogenicity. They are used for systemic treatment of certain disease. As the modern genomic and proteomic technology enables rapid screening of novel proteins and peptides as potential drug candidates, design of delivery systems for these biologics remains challenging especially to achieve site specific pharmacological actions. This article discusses the issues associated with targeted delivery of protein and peptide drugs.

Keywords


Peptides, Proteins, Drug Delivery, Site Specific, Genomic and Proteomic Technology, Targeted Delivery.

References