Antiulcer Activity of Natural Compounds:A Review

Peptic ulcer is a break in the lining of the stomach, first part of the small intestine, or duodenum. The duodenum is the first part of the small intestine. Contrary to popular belief, ulcers are not caused by spicy food or stress but instead are most commonly due to either an infection or long-term use of certain medications. The main goals for treating a peptic ulcer include eliminating the underlying cause (particularly H. pylori infection or use of NSAIDs), preventing further damage and complications, and reducing the risk of recurrence. Peptic ulcer which is mainly caused by bacterial attack or excess of acid secretion can be cured effectively by these isolated plant compounds. A number of drugs including proton pump inhibitors and H2 receptor antagonists are available for the treatment of peptic ulcer, but clinical evaluation of these drugs has shown incidence of relapses, side effects, and drug interactions. This has been the rationale for the development of new antiulcer drugs and the search for novel molecules has been extended to herbal drugs that offer better protection and decreased relapse. Craving for herbal medicines are still importance due lesser chance of adverse effects and easily available in surrounding place with low cost. In this review attempts have been made to summarize medicinal plants and their constituents used for peptic ulcer by the people of rural area which may be beneficial for the modern science.