Research Journal of Pharmacognosy and Phytochemistry

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Effect of Arogyavardhini in Experimental Prostatic Hyperplasia and Inflammation in Rats


Affiliations
1 Plot no 430, Sector No 28, Nigdi Pradhikaran, Pune, Maharashtra, Pin 411044, India
2 PDEA’s Seth Govind Raghunath Sable College of Pharmacy, Saswad, Pune, Maharashtra, India
3 TVES’s Loksevak Madhukarrao Chaudhari College of Pharmacy, Faizpur, Maharashtra, India
4 Rajgad Dyanpeeth’s College of Pharmacy, Bhor, Pune, Maharashtra, India
     

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Arogyavardhini, an Ayurvedic herbomineral formulation, was studied for its effect in experimental prostatic hyperplasia induced by testosterone injection s.c for 21 days in rats and inflammation induced in rat hind paw by carrageenan injection s.c. The results showed that Arogyavardhini at dosage of 100, 200 and 400 mg/kg orally for 21 days showed significant reduction of prostatic hyperplasia as indicated by decreased prostate weight and volume and hispathological observations. It also significantly inhibited carrageenan induced hind paw oedema in dose dependant manner. These results suggest that Arogyavardhini is effective in prostate disorder like Benign Prostatic Hyperplasia (BPH) by inhibiting proliferative and inflammatory mechanisms in prostate.


Keywords

Arogyavardhini, Herbomineral Preparation, Ayurvedic Formulation, Prostatic Hyperplasia, Anti Inflammatory.
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  • Effect of Arogyavardhini in Experimental Prostatic Hyperplasia and Inflammation in Rats

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Authors

R. K. Dumbre
Plot no 430, Sector No 28, Nigdi Pradhikaran, Pune, Maharashtra, Pin 411044, India
A. P. Kale
PDEA’s Seth Govind Raghunath Sable College of Pharmacy, Saswad, Pune, Maharashtra, India
V. R. Patil
TVES’s Loksevak Madhukarrao Chaudhari College of Pharmacy, Faizpur, Maharashtra, India
A. V. Bhosale
PDEA’s Seth Govind Raghunath Sable College of Pharmacy, Saswad, Pune, Maharashtra, India
M. B. Kamble
Rajgad Dyanpeeth’s College of Pharmacy, Bhor, Pune, Maharashtra, India

Abstract


Arogyavardhini, an Ayurvedic herbomineral formulation, was studied for its effect in experimental prostatic hyperplasia induced by testosterone injection s.c for 21 days in rats and inflammation induced in rat hind paw by carrageenan injection s.c. The results showed that Arogyavardhini at dosage of 100, 200 and 400 mg/kg orally for 21 days showed significant reduction of prostatic hyperplasia as indicated by decreased prostate weight and volume and hispathological observations. It also significantly inhibited carrageenan induced hind paw oedema in dose dependant manner. These results suggest that Arogyavardhini is effective in prostate disorder like Benign Prostatic Hyperplasia (BPH) by inhibiting proliferative and inflammatory mechanisms in prostate.


Keywords


Arogyavardhini, Herbomineral Preparation, Ayurvedic Formulation, Prostatic Hyperplasia, Anti Inflammatory.