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The Wound Healing, Anti Inflammatory and Haemostatic Effect of Eupatorium odoratum


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1 Department of Pharmacology, R.V.S. College Pharmaceutical Science, Sulur, Coimbatore-640 402, India
     

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Wound is perhaps an inescapable event in the life of an organism. Healing process begins during the early phase of inflammation, but reaches completion usually after the injurious influence has been neutralized. It should be emphasized that without inflammation wounds would never heal. Eupatorium odoratum Linn. (Family: Compositae) is a perennial herb growing widely in the south of the country. The wound healing effect of ethanol extract of E. odoratum was studied using, re sutured incision wound, excision wound model, dead space wound model and the results obtained by the three models were compared and found that excision wound model is statistically significant (p<0.01). The anti inflammatory activity of ethanolleaf extract of E. odoratum was evaluated using carregeenan induced paw edema in rats, there was no statistically significant change in the drug treated compared to the control and the haemostatic activity assessed by capillary tube method, there was a statically significant reduction in the blood coagulation time.

Keywords

Wound Healing, Anti Inflammatory, Haemostatic, Eupatorium odoratum.
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  • The Wound Healing, Anti Inflammatory and Haemostatic Effect of Eupatorium odoratum

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Authors

R. Suresh
Department of Pharmacology, R.V.S. College Pharmaceutical Science, Sulur, Coimbatore-640 402, India
D. Benito Johnson
Department of Pharmacology, R.V.S. College Pharmaceutical Science, Sulur, Coimbatore-640 402, India
Appalaraju Gorle
Department of Pharmacology, R.V.S. College Pharmaceutical Science, Sulur, Coimbatore-640 402, India
Ashok Kumar Javvadi
Department of Pharmacology, R.V.S. College Pharmaceutical Science, Sulur, Coimbatore-640 402, India
A. Tamil Selvan
Department of Pharmacology, R.V.S. College Pharmaceutical Science, Sulur, Coimbatore-640 402, India

Abstract


Wound is perhaps an inescapable event in the life of an organism. Healing process begins during the early phase of inflammation, but reaches completion usually after the injurious influence has been neutralized. It should be emphasized that without inflammation wounds would never heal. Eupatorium odoratum Linn. (Family: Compositae) is a perennial herb growing widely in the south of the country. The wound healing effect of ethanol extract of E. odoratum was studied using, re sutured incision wound, excision wound model, dead space wound model and the results obtained by the three models were compared and found that excision wound model is statistically significant (p<0.01). The anti inflammatory activity of ethanolleaf extract of E. odoratum was evaluated using carregeenan induced paw edema in rats, there was no statistically significant change in the drug treated compared to the control and the haemostatic activity assessed by capillary tube method, there was a statically significant reduction in the blood coagulation time.

Keywords


Wound Healing, Anti Inflammatory, Haemostatic, Eupatorium odoratum.