Open Access Open Access  Restricted Access Subscription Access
Open Access Open Access Open Access  Restricted Access Restricted Access Subscription Access

Free Radical Scavenging Activity and Cytotoxic Potential of Crude Extractives of Murraya paniculata (L.) Bark


Affiliations
1 Department of Pharmacy, Stamford University, 51, Siddeswari Road, Dhaka-1217, Bangladesh
2 Laboratory of Pharmacognosy and Pharmacology, Department of Pharmacy, Stamford University, Dhaka-1217, Bangladesh
     

   Subscribe/Renew Journal


The present study was accomplished to evaluate the crude methanolic extract of Murraya paniculata (L.) bark for in-vitro free radical scavenging activity by determination of hydrogen peroxide scavenging activity, total antioxidant capacity, assay of nitric oxide scavenging activity and reducing power test. Besides, the petroleum ether, chloroform and methanol extractives of bark were screened for brine shrimp lethality bio-assay to evaluate their cytotoxic potential. The results revealed the presence of pronounced antioxidant property as compared with ascorbic acid used as standard, as well as all the extractives of the plant showed strong lethality (LC50: 0.84±0.19 μg/ml, LC50: 1.17±0.03 μg/ml, LC50: 1.31±0.16 μg/ml, respectively) against brine shrimp nauplii, as compared with positive control, Vincristine Sulphate (LC50: 0.33±0.12 μg/ml).

Keywords

Murraya paniculata (L.), Rutaceae, Free Radical, Antioxidant, Brine Shrimp, Cytotoxicity.
Subscription Login to verify subscription
User
Notifications
Font Size


Abstract Views: 211

PDF Views: 0




  • Free Radical Scavenging Activity and Cytotoxic Potential of Crude Extractives of Murraya paniculata (L.) Bark

Abstract Views: 211  |  PDF Views: 0

Authors

Nowshin Nowaz Rumzhum
Department of Pharmacy, Stamford University, 51, Siddeswari Road, Dhaka-1217, Bangladesh
Md. Mostafizur Rahman
Laboratory of Pharmacognosy and Pharmacology, Department of Pharmacy, Stamford University, Dhaka-1217, Bangladesh
Md. Farhad Hossain
Laboratory of Pharmacognosy and Pharmacology, Department of Pharmacy, Stamford University, Dhaka-1217, Bangladesh

Abstract


The present study was accomplished to evaluate the crude methanolic extract of Murraya paniculata (L.) bark for in-vitro free radical scavenging activity by determination of hydrogen peroxide scavenging activity, total antioxidant capacity, assay of nitric oxide scavenging activity and reducing power test. Besides, the petroleum ether, chloroform and methanol extractives of bark were screened for brine shrimp lethality bio-assay to evaluate their cytotoxic potential. The results revealed the presence of pronounced antioxidant property as compared with ascorbic acid used as standard, as well as all the extractives of the plant showed strong lethality (LC50: 0.84±0.19 μg/ml, LC50: 1.17±0.03 μg/ml, LC50: 1.31±0.16 μg/ml, respectively) against brine shrimp nauplii, as compared with positive control, Vincristine Sulphate (LC50: 0.33±0.12 μg/ml).

Keywords


Murraya paniculata (L.), Rutaceae, Free Radical, Antioxidant, Brine Shrimp, Cytotoxicity.