Research Journal of Pharmacognosy and Phytochemistry

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Effect of leave Extract of Prunus persica Linn on Acute Inflammation in Rats


Affiliations
1 Sri Krupa Institute of Pharmaceutical Sciences, Vil. Velkatta, Kondapak (Mdl), Dist. Medak, Siddipet. Andhra Pradesh – 502277, India
2 Rajiv Gandhi College of Pharmacy, Nautanwa, Maharajganj, UP– 27316, India
3 I.B.S.D. Takyelpat ,Imphal, Manipur, India
4 Sri Krupa Institute of Pharmaceutical Sciences, Vil. Velkatta, Kondapak (Mdl), Dist. Medak, Siddipet. Andhra Pradesh – 502277, India
5 R. K. Pharmacy College, Kasipur, Suri – Santhiaon, Azamgarh, UP– 276001, India
     

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Prunus persica Linn (L) widely distributed in Manipur, India. The leaves were used in folklore/traditional medicine to treat several inflammatory pathologies such as greenish swelling (gland), oedema etc. Reactive oxygen species as well as reactive free radicals such as hydroxyl (OH), nitric oxide (NO) etc. contribute significantly to these pathologies. In this study, antiinflammatory activity of the aqueous extracts (AEPp) of Prunus persica L leaves was evaluated on carrageenin induced oedema. The test sample at the dose of 200 mg/kg/p.o. were found to cause significant (***P<0.001) inhibition of carrageenin induced oedema. The test samples AEPp show the protection against inflammation less than standard diclofenac sodium 8mg/kg b.w. These observations established the anti-inflammatory effect of Prunus persica L leaves aqueous extract in acute inflammation.

Keywords

Prunus persica, Inflammation.
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  • Effect of leave Extract of Prunus persica Linn on Acute Inflammation in Rats

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Authors

Chiranjib Bhattacharjee
Sri Krupa Institute of Pharmaceutical Sciences, Vil. Velkatta, Kondapak (Mdl), Dist. Medak, Siddipet. Andhra Pradesh – 502277, India
Durgesh Gupta
Rajiv Gandhi College of Pharmacy, Nautanwa, Maharajganj, UP– 27316, India
Lokesh Deb
I.B.S.D. Takyelpat ,Imphal, Manipur, India
C. Santhosh Kumar
Sri Krupa Institute of Pharmaceutical Sciences, Vil. Velkatta, Kondapak (Mdl), Dist. Medak, Siddipet. Andhra Pradesh – 502277, India
Subal Debnath
Sri Krupa Institute of Pharmaceutical Sciences, Vil. Velkatta, Kondapak (Mdl), Dist. Medak, Siddipet. Andhra Pradesh – 502277, India
A. S. Dutta
R. K. Pharmacy College, Kasipur, Suri – Santhiaon, Azamgarh, UP– 276001, India

Abstract


Prunus persica Linn (L) widely distributed in Manipur, India. The leaves were used in folklore/traditional medicine to treat several inflammatory pathologies such as greenish swelling (gland), oedema etc. Reactive oxygen species as well as reactive free radicals such as hydroxyl (OH), nitric oxide (NO) etc. contribute significantly to these pathologies. In this study, antiinflammatory activity of the aqueous extracts (AEPp) of Prunus persica L leaves was evaluated on carrageenin induced oedema. The test sample at the dose of 200 mg/kg/p.o. were found to cause significant (***P<0.001) inhibition of carrageenin induced oedema. The test samples AEPp show the protection against inflammation less than standard diclofenac sodium 8mg/kg b.w. These observations established the anti-inflammatory effect of Prunus persica L leaves aqueous extract in acute inflammation.

Keywords


Prunus persica, Inflammation.