Studies on Anti-Inflammatory and Analgesic Properties of Methanol Extract of Aerial Part of Clerodendrum inerme in Experimental Animal Models

The methanol extract of aerial part of Clerodendrum inerme were investigated for anti-inflammatory and analgesic at the dose 200 mg/kg, body weight. The experimental paradigms used were carrageenan, induced pedal edema for anti-inflammatory activity, acetic acid induced writhing methods were used to assess analgesic activity. In acute phase inflammation, a maximum inhibition 60.17% (P < 0.01) was noted at the dose of 200 mg/kg after 3 h of treatment with methanol extract of Clerodendrum inerme (MECI) in carrageenan, induced pedal edema respectively. The extract also produced significant (P < 0.01) analgesic activity in both paradigms. This study exhibits that the methanol extracts of aerial part of Clerodendrum inerme possess anti-inflammatory and analgesic activities.