Research Journal of Pharmacognosy and Phytochemistry

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Antihyperglycemic Activity of Strychnos potatorum Seed and Leaf Methanolic Extracts in Alloxan-Induced Diabetic Rats


Affiliations
1 Vaagdevi College of Pharmacy, Kishanpura, Hanumakonda, Warangal-506001, (AP), India
2 Department of Ayurvedic, Ananthalaxmi Ayurvedic Government Medical College, Warangal, Andhra Pradesh, India
3 Department of Pharmacognosy, Vaagdevi College of Pharmacy, Hanumakonda, Warangal, Andhra Pradesh, India
     

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The pharmacognostic and phytochemical examinations of different solvents extracts of seeds and leaves of Strychnos potatorum were conducted and their antidiabetic activity was evaluated.The administration of methanolic extracts of seeds and leaves of Strychnos potatorum by oral route at doses; 200 and 400 mg/kg b.w. at every 3 hour interval reduced blood glucose levels by24.23%, 25.67%, 16.47% and 17.88%, respectively in alloxan-induced diabetic rats.

Keywords

Strychnos potatorum, Alloxan, Antihyperglycemic Activity, Loganiaceae, MESP (Methanolic Extract of Seed Powder), MELP (Methanolic Extract of Leaf Powder).
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  • Antihyperglycemic Activity of Strychnos potatorum Seed and Leaf Methanolic Extracts in Alloxan-Induced Diabetic Rats

Abstract Views: 275  |  PDF Views: 0

Authors

T. Pandu Raju
Vaagdevi College of Pharmacy, Kishanpura, Hanumakonda, Warangal-506001, (AP), India
K. J. R. Shastri
Department of Ayurvedic, Ananthalaxmi Ayurvedic Government Medical College, Warangal, Andhra Pradesh, India
C. Srinivas Reddy
Department of Pharmacognosy, Vaagdevi College of Pharmacy, Hanumakonda, Warangal, Andhra Pradesh, India
V. M. Reddy
Department of Pharmacognosy, Vaagdevi College of Pharmacy, Hanumakonda, Warangal, Andhra Pradesh, India

Abstract


The pharmacognostic and phytochemical examinations of different solvents extracts of seeds and leaves of Strychnos potatorum were conducted and their antidiabetic activity was evaluated.The administration of methanolic extracts of seeds and leaves of Strychnos potatorum by oral route at doses; 200 and 400 mg/kg b.w. at every 3 hour interval reduced blood glucose levels by24.23%, 25.67%, 16.47% and 17.88%, respectively in alloxan-induced diabetic rats.

Keywords


Strychnos potatorum, Alloxan, Antihyperglycemic Activity, Loganiaceae, MESP (Methanolic Extract of Seed Powder), MELP (Methanolic Extract of Leaf Powder).