Hypoglycemic Effect of Foeniculum vulgare Mill. Fruit on Dexamethasone Induced Insulin Resistance Rats

Aim: - To assess the hypoglycemic effect of Foeniculum vulgare Mill. Fruit on dexamethasone induced insulin resistance rats.

Method: - Wistar male rats (n=5) were made insulin resistance by administering dexamethasone injection subcutaneously to the overnight fasted rats and continue till the end of the experiment along with methanolic extract of Foeniculum vulgare Mill. Fruit for test and pioglitazone for std. At the end of the experimental period i.e. on day 11th the animals anesthetize with ether, blood was collected by retroobital puncture and serum separated for the estimation of glucose, triglycerides, cholesterol, insulin. The animals were weighed at the beginning and at the end of experimental period. The liver and muscle glycogen was also measured.

Results: - Methanolic extract of Foeniculum vulgare Mill. Fruit lowers blood glucose, triglycerides, cholesterol and increase liver and muscle glycogen in dexamethasone induced insulin resistance rats.

Conclusion: The present study was indicating that Foeniculum vulgare Mill. Fruit showed significant glucose and triglyceride lowering activities as compared with diabetic control. In comparison with standard pioglitazone, Foeniculum vulgare Mill. Fruit showed comparable serum glucose lowering and better triglyceride lowering activity.