Evaluation of Anti-Inflammatory, Antipyretic and Antifungal Activity of Solanum laeve Dunal

Solanum leave Dunal var biegninatum is small shrub is used by the tribals as a medicinal plant. The objective of the present investigation was to study the anti inflammatory, antipyretic and anti fungal activity potential in experimental animal models. The isolated compounds obtained from the chromatography after the extraction completed were used for (SA-I, SA-II, SA-III) these studies. Anti inflammatory potential of isolated compounds (SA-I, SA-II, SA-III) was evaluated by Carrageenan induced paw edema method in rats. Also antipyretic activity was tested on animal models. The studies were conducted on wistar rats of either sex (160-180g). The change in edema volume of the rat hind paw was measured using plethysmometer. The SA-III of isolated compound of Solanum leave dunal inhibited the formation of edema to significant levels in rats treated with carrageenan. At a dose of 100mg/kg orally, the SA-III produced 40.90% inhibition in case of the carrageenan induced edema (p<0.01).

The isolated compounds of Solanum leave Dunal (SA-I, SA-II,SA-III) were also evaluated for antipyretic activity on animals as per Vogel's method. Solanum leave Dunal elicited a dose dependent inhibition of rectal temperature compared with control group. The isolated compound SA-II having maximum antipyretic activity which was compared with standard inhibition at 300mg/kg p.o.

The fungal activity of the isolated compounds (SA-I,SA-II,SA-III) were prepared at various concentration of 1%,2% and 3% solution respectively. In this the compound SA-II(C) having significant antifungal activity compared with other compound against Candida albicans.

The results indicated that the isolated compounds (SA-I,SA-II,SA-III) were active against all the experimentally induced laboratory models of inflammation, pyretic activities and also antifungal activity.