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Evaluation of Wound Healing Potential of Ethanolic Extracts of Various Parts of Phyllanthus simplex Retz


Affiliations
1 KVSR Siddhartha College of Pharmaceutical Sciences, Vijayawada-520 010. Andhra Pradesh, India
2 Department of Microbiology, Acharya Nagarjuna University, Acharyanagar, Guntur, Andhra Pradesh, India
3 KVSR Siddhartha College of Pharmaceutical Sciences, Vijayawada-520 010, Andhra Pradesh, India
     

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Wound healing is a complex dynamic process that results in the restoration of anatomic continuity and function. The present study has proved that the wound healing potential of ethanolic extract obtained from ischolar_mains of Phyllanthus simplex Retz showed a significant effect than the same extract obtained from other parts of the plant. That extract showed a facilitatory epithelisation and wound contraction than other parts extracts. The ischolar_main extract animal groups showed a high collagen content than other extracts and the control groups. Hexosamine content and ascorbic acid levels showed an increased level of the extract. Ascorbic acid is reported to have scavenging activity and inhibition of lipid peroxidation, which helps to show a better healing effect for the test groups.


Keywords

Wound Healing, Collagen, Hydroxy Proline, Hexose Amine, Epithelization.
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  • Evaluation of Wound Healing Potential of Ethanolic Extracts of Various Parts of Phyllanthus simplex Retz

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Authors

Arasan Elayaraja
KVSR Siddhartha College of Pharmaceutical Sciences, Vijayawada-520 010. Andhra Pradesh, India
M. Vijayalakshmi
Department of Microbiology, Acharya Nagarjuna University, Acharyanagar, Guntur, Andhra Pradesh, India
Devalarao Garikapati
KVSR Siddhartha College of Pharmaceutical Sciences, Vijayawada-520 010, Andhra Pradesh, India

Abstract


Wound healing is a complex dynamic process that results in the restoration of anatomic continuity and function. The present study has proved that the wound healing potential of ethanolic extract obtained from ischolar_mains of Phyllanthus simplex Retz showed a significant effect than the same extract obtained from other parts of the plant. That extract showed a facilitatory epithelisation and wound contraction than other parts extracts. The ischolar_main extract animal groups showed a high collagen content than other extracts and the control groups. Hexosamine content and ascorbic acid levels showed an increased level of the extract. Ascorbic acid is reported to have scavenging activity and inhibition of lipid peroxidation, which helps to show a better healing effect for the test groups.


Keywords


Wound Healing, Collagen, Hydroxy Proline, Hexose Amine, Epithelization.